Pulsenmore Ltd Ordinary Shares (PLSM) had the highest return in December 2025 by a micro-cap US stock, returning 703.2%.

ASSET	MONTH	% RETURN
Pulsenmore Ltd Ordinary Shares (PLSM)	December 2025	703.15%
Aptorum Group Ltd Class A (APM)	December 2025	679.41%
Aimei Health Technology Co, Ltd Ordinary Share (AFJK)	December 2025	471.52%
Sidus Space (SIDU)	December 2025	349.21%
Heartbeam (BEAT)	December 2025	261.45%
Society Pass (SOPA)	December 2025	183.58%
Polyrizon Ltd Ordinary Shares (PLRZ)	December 2025	160.43%
ICZOOM Group Inc Class A Ordinary Shares (IZM)	December 2025	154%
Ascent Solar Technologies, Inc Common Stock (ASTI)	December 2025	150.61%
Greenwich Lifesciences (GLSI)	December 2025	147.18%
Lipocine (LPCN)	December 2025	140.56%
TROOPS (TROO)	December 2025	133.58%
Grande Group Limited Class A Ordinary Shares (GRAN)	December 2025	125.23%
cbdMD (YCBD)	December 2025	120.95%
Ampco-Pittsburgh (AP)	December 2025	110.67%
FAST TRACK (FTRK)	December 2025	91.77%
Eva Live Inc Common Stock (GOAI)	December 2025	87.5%
Micromobility (MCOM)	December 2025	83.33%
GridAI Technologies (GRDX)	December 2025	82.75%
PetMed Express (PETS)	December 2025	81.82%
Fenbo Holdings Limited Ordinary Shares (FEBO)	December 2025	80.95%
Designer Brands (DBI)	December 2025	78.38%
Equillium (EQ)	December 2025	74.41%
Comtech Telecommunications (CMTL)	December 2025	74.01%
Cumberland Pharmaceuticals (CPIX)	December 2025	73.8%

Micro-cap stocks are treated as having a market cap of <= $300M.