Applied Digital (APLD) had the highest return between 2020 and 2025 by a mid-cap US stock, returning 340,455.6%.

ASSET	YEARS	% RETURN
Applied Digital (APLD)	2020-2025	340,455.56%
Sapiens International (SPNS)	2020-2025	66,862.36%
QMMM Holdings Limited Ordinary Shares (QMMM)	2020-2025	3,880%
Centrus Energy (LEU)	2020-2025	3,428.49%
Galaxy Digital (GLXY)	2020-2025	2,657.43%
Alpha Metallurgical Resources (AMR)	2020-2025	2,236.88%
Sterling Construction (STRL)	2020-2025	2,047.48%
Modine Manufacturing (MOD)	2020-2025	1,609.48%
Sezzle (SEZL)	2020-2025	1,581.46%
IES (IESC)	2020-2025	1,396.23%
Sitime (SITM)	2020-2025	1,258.42%
GameStop (GME)	2020-2025	1,208.14%
Belite Bio Inc ADR (BLTE)	2020-2025	1,179.68%
Indivior PLC Ordinary Shares (INDV)	2020-2025	1,172.34%
Uranium Energy (UEC)	2020-2025	1,155.91%
Protagonist Therapeutics (PTGX)	2020-2025	1,131.88%
Cogent Biosciences (COGT)	2020-2025	1,100%
Abivax SA American Depositary Shares (ABVX)	2020-2025	1,062.54%
Taseko Mines (TGB)	2020-2025	1,055.1%
Hut 8 Corp Common Stock (HUT)	2020-2025	1,044.21%
Riot Blockchain (RIOT)	2020-2025	1,011.4%
Skeena Resources (SKE)	2020-2025	991.44%
Bel Fuse A (BELFA)	2020-2025	908.56%
New Gold (NGD)	2020-2025	867.78%
Camtek (CAMT)	2020-2025	860.82%

Mid-cap stocks are treated as having a market cap between $2B and $10B.