Natwest (NWG) had the highest return between 2004 and 2007 by a US stock with a market cap of $2B+, returning 9,034,940%.

ASSET	YEARS	% RETURN
Natwest (NWG)	2004-2007	9,034,940%
Northern Oil & Gas (NOG)	2004-2007	2,241,830.77%
National Grid PLC ADR (NGG)	2004-2007	1,604,552.94%
Monster Beverage (MNST)	2004-2007	4,108.44%
Intuitive Surgical (ISRG)	2004-2007	1,788.89%
Apple (AAPL)	2004-2007	1,738.71%
Banco Bradesco SA ADR (BBD)	2004-2007	1,084.11%
DXP Enterprises (DXPE)	2004-2007	1,024.82%
First Solar (FSLR)	2004-2007	990.37%
Vale SA ADR (VALE)	2004-2007	941.22%
BlackBerry (BB)	2004-2007	913.1%
Suzano Papel e Celulose SA ADR (SUZ)	2004-2007	895.66%
CME (CME)	2004-2007	871.35%
Companhia Siderurgica Nacional ADR (SID)	2004-2007	870.45%
ArcelorMittal SA ADR (MT)	2004-2007	866.45%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2004-2007	859.31%
Mosaic (MOS)	2004-2007	824.9%
RadNet (RDNT)	2004-2007	822.73%
BRF SA ADR (BRFS)	2004-2007	822.65%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2004-2007	808.69%
Seabridge Gold (SA)	2004-2007	753.33%
Cleveland-Cliffs (CLF)	2004-2007	715.12%
Illumina (ILMN)	2004-2007	711.78%
Gerdau SA ADR (GGB)	2004-2007	689.79%
GameStop (GME)	2004-2007	686.19%