Hirequest (HQI) had the highest return between 2000 and 2006 by a US stock, returning 27,792,300%.

ASSET	YEARS	% RETURN
Hirequest (HQI)	2000-2006	27,792,300%
InterContinental Hotels Group PLC ADR (IHG)	2000-2006	16,461,200%
India Globalization Capital (IGC)	2000-2006	9,733,233.33%
Know Labs (KNW)	2000-2006	7,785,769.97%
Cemtrex (CETX)	2000-2006	4,938,903.31%
Houston American Energy (HUSA)	2000-2006	1,905,180.67%
Perspective Therapeutics (CATX)	2000-2006	1,633,233.33%
National Grid PLC ADR (NGG)	2000-2006	1,344,788.24%
Ocean Power Technologies (OPTT)	2000-2006	188,788.89%
ImmunoPrecise Antibodies (HYFT)	2000-2006	35,900%
Gyre Therapeutics (GYRE)	2000-2006	19,089.16%
First Majestic Silver (AG)	2000-2006	18,233.33%
Gulf Resources (GURE)	2000-2006	13,400%
NanoViricides (NNVC)	2000-2006	10,260%
TherapeuticsMD (TXMD)	2000-2006	9,900.01%
Oramed Pharmaceuticals (ORMP)	2000-2006	6,866.14%
Monster Beverage (MNST)	2000-2006	6,193.05%
Dmc Global (BOOM)	2000-2006	4,441.47%
OPTIMIZERx (OPRX)	2000-2006	4,400%
US Global Investors (GROW)	2000-2006	4,034.03%
Denison Mines (DNN)	2000-2006	4,004.62%
Clean Harbors (CLH)	2000-2006	3,871.94%
MEDIFAST (MED)	2000-2006	3,555.55%
Cryoport (CYRX)	2000-2006	3,532.43%
HF Sinclair (DINO)	2000-2006	3,429.81%