NVIDIA (NVDA) has had the highest return between 2018 and 2025 by a US stock in the S&P 500 (GSPC), returning 3,747.6%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2018-2025	3,747.63%
Axon Enterprise (AXON)	2018-2025	2,675.08%
Advanced Micro Devices (AMD)	2018-2025	2,327.26%
Super Micro Computer (SMCI)	2018-2025	2,210.53%
Tesla (TSLA)	2018-2025	1,985.19%
Palantir Technologies Inc Class A Common Stock (PLTR)	2018-2025	1,746.3%
Broadcom (AVGO)	2018-2025	1,595.31%
Vistra Energy (VST)	2018-2025	1,187.97%
KLA-Tencor (KLAC)	2018-2025	1,163.07%
Quanta Services (PWR)	2018-2025	1,043.8%
Trade Desk (TTD)	2018-2025	1,038.1%
Eli Lilly and (LLY)	2018-2025	999.36%
Fair Isaac (FICO)	2018-2025	986.63%
Constellation Energy (CEG)	2018-2025	957.98%
Arista Networks (ANET)	2018-2025	944.7%
Monolithic Power Systems (MPWR)	2018-2025	913.87%
Fortinet (FTNT)	2018-2025	877.61%
Howmet Aerospace (HWM)	2018-2025	877.26%
EMCOR (EME)	2018-2025	840.58%
Lam Research (LRCX)	2018-2025	816.49%
Palo Alto Networks (PANW)	2018-2025	792.23%
Applovin (APP)	2018-2025	785.71%
Williams-Sonoma (WSM)	2018-2025	769.59%
Jabil Circuit (JBL)	2018-2025	743.4%
Crowdstrike (CRWD)	2018-2025	730.43%