Monster Beverage (MNST) had the highest return between 2002 and 2020 by a US stock in the S&P 500 (GSPC), returning 104,515.4%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2002-2020	104,515.38%
Netflix (NFLX)	2002-2020	46,659.77%
Apple (AAPL)	2002-2020	38,949.41%
Amazon (AMZN)	2002-2020	29,681.73%
Deckers Outdoor (DECK)	2002-2020	19,361.2%
Tesla (TSLA)	2002-2020	18,469.76%
Old Dominion Freight Line (ODFL)	2002-2020	16,891.19%
Texas Pacific Land Trust (TPL)	2002-2020	13,006.43%
Intuitive Surgical (ISRG)	2002-2020	12,421.24%
Align Technology (ALGN)	2002-2020	11,775.11%
Axon Enterprise (AXON)	2002-2020	10,656.74%
Tyler Technologies (TYL)	2002-2020	9,493.85%
Mastercard (MA)	2002-2020	9,374.69%
Tractor Supply (TSCO)	2002-2020	7,299.72%
IDEXX Laboratories (IDXX)	2002-2020	6,747.53%
Booking (BKNG)	2002-2020	6,256.35%
Salesforce (CRM)	2002-2020	5,834.24%
Transdigm (TDG)	2002-2020	5,812.43%
Domino's Pizza Inc Common Stock (DPZ)	2002-2020	5,657.75%
West Pharmaceutical Services (WST)	2002-2020	5,459.69%
Cognizant Technology Solutions Corp Class A (CTSH)	2002-2020	4,918.39%
Monolithic Power Systems (MPWR)	2002-2020	4,453.6%
Rollins (ROL)	2002-2020	4,224.19%
Edwards Lifesciences (EW)	2002-2020	3,859.29%
CME (CME)	2002-2020	3,837.17%