Metalla Royalty & Streaming (MTA) had the highest return between 2009 and 2010 by a small-cap US stock, returning 9,542.2%.

ASSET	YEARS	% RETURN
Metalla Royalty & Streaming (MTA)	2009-2010	9,542.17%
Mitek Systems (MITK)	2009-2010	7,462.5%
IDT (IDT)	2009-2010	2,301.44%
Vanda Pharmaceuticals (VNDA)	2009-2010	1,902.12%
MGP Ingredients (MGPI)	2009-2010	1,553.4%
TriMas (TRS)	2009-2010	1,404.44%
Amarin (AMRN)	2009-2010	1,088.41%
Know Labs (KNW)	2009-2010	966.67%
Galectin Therapeutics (GALT)	2009-2010	900%
Galiano Gold (GAU)	2009-2010	835.11%
Clearwater Paper (CLW)	2009-2010	827.73%
Newtek Business Services (NEWT)	2009-2010	800.03%
Delcath Systems (DCTH)	2009-2010	789.13%
Taseko Mines (TGB)	2009-2010	774.85%
McEwen Mining (MUX)	2009-2010	767.79%
China Yuchai International (CYD)	2009-2010	750.47%
Acacia Research (ACTG)	2009-2010	747.71%
International Tower Hill Mines (THM)	2009-2010	728.26%
Gyre Therapeutics (GYRE)	2009-2010	642.36%
Allot Communications (ALLT)	2009-2010	605.45%
Radware (RDWR)	2009-2010	589.52%
Veeco Instruments (VECO)	2009-2010	577.6%
Avino Silver & Gold Mines (ASM)	2009-2010	561.9%
Magic Software Enterprises (MGIC)	2009-2010	532.41%
Imax (IMAX)	2009-2010	527.96%

Small-cap stocks are treated as having a market cap between $300M and $2B.