Metalla Royalty & Streaming (MTA) had the highest return between 2015 and 2016 by a small-cap US stock, returning 1,566.4%.

ASSET	YEARS	% RETURN
Metalla Royalty & Streaming (MTA)	2015-2016	1,566.43%
eXp World (EXPI)	2015-2016	1,272.54%
Cronos (CRON)	2015-2016	564.34%
EVI Industries (EVI)	2015-2016	458.84%
Anavex Life Sciences (AVXL)	2015-2016	421.05%
Northern Dynasty Minerals (NAK)	2015-2016	392.86%
Canopy Growth (CGC)	2015-2016	298.83%
Central Garden & Pet (CENT)	2015-2016	277.31%
LeMaitre Vascular (LMAT)	2015-2016	252.13%
HIVE Blockchain Technologies (HIVE)	2015-2016	242.86%
New Pacific Metals (NEWP)	2015-2016	242.86%
GoldMining (GLDG)	2015-2016	233.69%
Central Garden & Pet Company A (CENTA)	2015-2016	220.54%
Five9 (FIVN)	2015-2016	216.04%
MGP Ingredients (MGPI)	2015-2016	215.67%
Amarin (AMRN)	2015-2016	214.29%
Contango ORE (CTGO)	2015-2016	206.73%
Meta Financial (CASH)	2015-2016	201.14%
Empresa Distribuidora y Comercializadora Norte SA ADR (EDN)	2015-2016	194.09%
MaxLinear (MXL)	2015-2016	191.83%
Federal Agricultural Mortgage (AGM.A)	2015-2016	183.4%
Evotec SE ADR (EVO)	2015-2016	177.96%
McEwen Mining (MUX)	2015-2016	167.7%
Cantaloupe (CTLP)	2015-2016	165.43%
Gibraltar Industries (ROCK)	2015-2016	154.9%

Small-cap stocks are treated as having a market cap between $300M and $2B.