Amerant Bancorp (AMTB) had the highest return between 2018 and 2022 by a small-cap US stock, returning 8,533,633.3%.

ASSET	YEARS	% RETURN
Amerant Bancorp (AMTB)	2018-2022	8,533,633.33%
Diversified Energy (DEC)	2018-2022	579,200%
Immatics (IMTX)	2018-2022	174,100%
Integra Resources (ITRG)	2018-2022	105,400%
Delcath Systems (DCTH)	2018-2022	6,903.89%
Xpel (XPEL)	2018-2022	4,100%
Tandem Diabetes Care (TNDM)	2018-2022	1,812.77%
Sigma Lithium Resources (SGML)	2018-2022	1,802.9%
Atlanticus (ATLC)	2018-2022	991.67%
Harrow Health (HROW)	2018-2022	768.24%
Digital Turbine (APPS)	2018-2022	746.67%
Perion Network (PERI)	2018-2022	734.98%
Clearfield (CLFD)	2018-2022	674.81%
Know Labs (KNW)	2018-2022	661.9%
Aehr Test Systems (AEHR)	2018-2022	641.7%
BlueLinx (BXC)	2018-2022	627.84%
Osisko Development (ODV)	2018-2022	582%
Fulgent Genetics (FLGT)	2018-2022	579.91%
Vaalco Energy (EGY)	2018-2022	543.77%
NAPCO Security Technologies (NSSC)	2018-2022	535.38%
Amark Preci (AMRK)	2018-2022	462.3%
Byrna Technologies (BYRN)	2018-2022	460%
InMode (INMD)	2018-2022	428.89%
IsoEnergy (ISOU)	2018-2022	418.21%
Transcat (TRNS)	2018-2022	397.33%

Small-cap stocks are treated as having a market cap between $300M and $2B.