Bank of NT Butterfield & Son (NTB) had the highest return between 2008 and 2024 by a small-cap US stock, returning 3,534,480%.

ASSET	YEARS	% RETURN
Bank of NT Butterfield & Son (NTB)	2008-2024	3,534,480%
Immatics (IMTX)	2008-2024	142,100%
NioCorp Developments Ltd Common Stock (NB)	2008-2024	91,076.47%
LifeMD (LFMD)	2008-2024	8,150%
Vera Therapeutics (VERA)	2008-2024	5,614.86%
Clearfield (CLFD)	2008-2024	3,824.05%
Metalla Royalty & Streaming (MTA)	2008-2024	3,640.69%
ePlus (PLUS)	2008-2024	3,369.36%
UFP Technologies (UFPT)	2008-2024	3,164.49%
Virtus Investment Partners (VRTS)	2008-2024	3,000.64%
BioLife Solutions (BLFS)	2008-2024	2,990.48%
Climb Global Solutions (CLMB)	2008-2024	2,876.61%
Mitek Systems (MITK)	2008-2024	2,828.95%
Par Pacific (PARR)	2008-2024	2,631.67%
Winmark (WINA)	2008-2024	2,344.45%
eXp World (EXPI)	2008-2024	2,302.24%
Site Centers (SITC)	2008-2024	2,178.13%
Xpel (XPEL)	2008-2024	2,002.11%
Travere Therapeutics (TVTX)	2008-2024	1,835.56%
EVI Industries (EVI)	2008-2024	1,733.17%
John B Sanfilippo & Son (JBSS)	2008-2024	1,618.69%
Willis Lease Finance (WLFC)	2008-2024	1,574.69%
Federal Agricultural Mortgage (AGM.A)	2008-2024	1,427.7%
NeoGenomics (NEO)	2008-2024	1,425.93%
Transcat (TRNS)	2008-2024	1,412.73%

Small-cap stocks are treated as having a market cap between $300M and $2B.