180 Life Sciences (ATNF) had the highest return between 2019 and 2020 by a small-cap US stock, returning 3,870,795.5%.

ASSET	YEARS	% RETURN
180 Life Sciences (ATNF)	2019-2020	3,870,795.52%
Integra Resources (ITRG)	2019-2020	979,900%
Fubotv (FUBO)	2019-2020	15,719.21%
Digital Turbine (APPS)	2019-2020	2,957.3%
Kodiak Sciences (KOD)	2019-2020	1,980.88%
Fulgent Genetics (FLGT)	2019-2020	1,543.53%
NRx Pharmaceuticals (NRXPW)	2019-2020	1,466.67%
Daqo New Energy Corp ADR (DQ)	2019-2020	1,146.41%
HIVE Blockchain Technologies (HIVE)	2019-2020	869.23%
Clearpoint Neuro (CLPT)	2019-2020	868.9%
Byrna Technologies (BYRN)	2019-2020	866.67%
Advent Technologies (ADNWW)	2019-2020	865.71%
Arcturus Therapeutics (ARCT)	2019-2020	857.62%
Ballard Power Systems (BLDP)	2019-2020	855.1%
Pennant (PNTG)	2019-2020	844.07%
Fiverr International (FVRR)	2019-2020	829.05%
EverQuote Inc Class A (EVER)	2019-2020	797.84%
Microvision (MVIS)	2019-2020	796.67%
eXp World (EXPI)	2019-2020	796.6%
Xpel (XPEL)	2019-2020	748.03%
Aspen Aerogels (ASPN)	2019-2020	683.57%
Mind Medicine (MNMD)	2019-2020	675.21%
Veritone (VERI)	2019-2020	656.65%
Atlanticus (ATLC)	2019-2020	587.99%
Arvinas (ARVN)	2019-2020	571.38%

Small-cap stocks are treated as having a market cap between $300M and $2B.