best performing small-cap stocks from january 2000 to january 2022

Amerant Bancorp (AMTB) had the highest return between January 1, 2000 and January 31, 2022 by a small-cap US stock, returning 10,681,500%.

ASSET DATE % RETURN
Amerant Bancorp (AMTB)
1/1/2000 - 1/31/2022
10,681,500%
OPTIMIZERx (OPRX)
1/1/2000 - 1/31/2022
449,200%
Integra Resources (ITRG)
1/1/2000 - 1/31/2022
375,900%
Immatics (IMTX)
1/1/2000 - 1/31/2022
201,700%
Know Labs (KNW)
1/1/2000 - 1/31/2022
157,660.81%
Diversified Energy (DEC)
1/1/2000 - 1/31/2022
22,650%
Metalla Royalty & Streaming (MTA)
1/1/2000 - 1/31/2022
21,802.43%
Simulations Plus (SLP)
1/1/2000 - 1/31/2022
10,654.42%
Mesa Laboratories (MLAB)
1/1/2000 - 1/31/2022
9,614.07%
Nutex Health (NUTX)
1/1/2000 - 1/31/2022
8,500%
USANA Health Sciences (USNA)
1/1/2000 - 1/31/2022
7,767.96%
Neogen (NEOG)
1/1/2000 - 1/31/2022
7,714.44%
Helios Technologies (HLIO)
1/1/2000 - 1/31/2022
7,514.75%
NAPCO Security Technologies (NSSC)
1/1/2000 - 1/31/2022
6,943.86%
Mesabi Trust (MSB)
1/1/2000 - 1/31/2022
6,752.49%
Winmark (WINA)
1/1/2000 - 1/31/2022
6,619.32%
eXp World (EXPI)
1/1/2000 - 1/31/2022
5,337.4%
Cryoport (CYRX)
1/1/2000 - 1/31/2022
4,415.68%
Hingham Institution for Savings (HIFS)
1/1/2000 - 1/31/2022
4,410.35%
HIVE Blockchain Technologies (HIVE)
1/1/2000 - 1/31/2022
4,188.79%
World Acceptance (WRLD)
1/1/2000 - 1/31/2022
3,986.05%
US Physicalrapy (USPH)
1/1/2000 - 1/31/2022
3,913.24%
Transcat (TRNS)
1/1/2000 - 1/31/2022
3,844.23%
China Yuchai International (CYD)
1/1/2000 - 1/31/2022
3,666.43%
Universal Insurance (UVE)
1/1/2000 - 1/31/2022
3,460.59%
Small-cap stocks are treated as having a market cap between $300M and $2B.