InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1995 and 2010 by a US stock, returning 14,004,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1995-2010	14,004,900%
Northern Oil & Gas (NOG)	1995-2010	8,777,303.85%
QVC (QVCGA)	1995-2010	8,177,603.7%
AngloGold Ashanti (AU)	1995-2010	6,910,650%
Know Labs (KNW)	1995-2010	4,885,152.16%
Houston American Energy (HUSA)	1995-2010	4,701,043.45%
Hirequest (HQI)	1995-2010	2,146,250%
National Grid PLC ADR (NGG)	1995-2010	1,128,370.59%
India Globalization Capital (IGC)	1995-2010	966,566.67%
Natwest (NWG)	1995-2010	774,270%
Ferguson (FERG)	1995-2010	431,485.11%
Perspective Therapeutics (CATX)	1995-2010	376,566.67%
Aris Mining (ARMN)	1995-2010	326,680.13%
Ring Energy (REI)	1995-2010	133,233.33%
Inuvo (INUV)	1995-2010	113,677.78%
First Majestic Silver (AG)	1995-2010	63,584%
Ocean Power Technologies (OPTT)	1995-2010	63,455.56%
Gyre Therapeutics (GYRE)	1995-2010	56,089.27%
Pioneer Power Solutions (PPSI)	1995-2010	29,429.23%
Future Fintech (FTFT)	1995-2010	23,150%
Monster Beverage (MNST)	1995-2010	22,951.32%
Companhia Siderurgica Nacional ADR (SID)	1995-2010	21,776.22%
Flexible Solutions International (FSI)	1995-2010	20,896.08%
NanoViricides (NNVC)	1995-2010	20,480%
Biogen (BIIB)	1995-2010	18,290.02%