DarioHealth (DRIO) had the highest return between 2016 and 2021 by a US stock, returning 25,939,900%.

ASSET	YEARS	% RETURN
DarioHealth (DRIO)	2016-2021	25,939,900%
Amerant Bancorp (AMTB)	2016-2021	10,854,266.67%
BioNexus Gene Lab Corp Common stock (BGLC)	2016-2021	6,234,046.34%
180 Life Sciences (ATNF)	2016-2021	5,811,664.71%
KULR Technology (KULR)	2016-2021	5,519,900%
GreenPower Motor (GP)	2016-2021	2,962,400%
Freedom (FRHC)	2016-2021	1,612,225.58%
TNF Pharmaceuticals (TNFA)	2016-2021	1,394,071.93%
GeoVax Labs (GOVX)	2016-2021	1,108,063.27%
AquaBounty Technologies (AQB)	2016-2021	583,233.33%
Weatherford International (WFRD)	2016-2021	477,031.58%
Integra Resources (ITRG)	2016-2021	429,900%
Connexa Sports Technologies (YYAI)	2016-2021	275,100%
Immatics (IMTX)	2016-2021	268,700%
MDxHealth SA ADR (MDXH)	2016-2021	226,566.67%
Guardforce AI (GFAI)	2016-2021	207,592.31%
Bone Biologics (BBLG)	2016-2021	123,529.26%
ImmunoPrecise Antibodies (HYFT)	2016-2021	35,633.33%
Applied Digital (APLD)	2016-2021	32,130.77%
Blackboxstocks (BLBX)	2016-2021	31,079.04%
Diversified Energy (DEC)	2016-2021	22,800%
Alarum Technologies (ALAR)	2016-2021	20,843.95%
Metalla Royalty & Streaming (MTA)	2016-2021	19,885.22%
Avalon GloboCare (ALBT)	2016-2021	17,471.43%
HIVE Blockchain Technologies (HIVE)	2016-2021	16,400%