InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1999 and 2004 by a US stock, returning 8,020,800%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1999-2004	8,020,800%
Hirequest (HQI)	1999-2004	4,127,500%
Inseego (INSG)	1999-2004	323,400%
Houston American Energy (HUSA)	1999-2004	244,859.25%
NextTrip (NTRP)	1999-2004	191,900%
ImmunoPrecise Antibodies (HYFT)	1999-2004	85,614.29%
Flexible Solutions International (FSI)	1999-2004	66,170.59%
Insmed (INSM)	1999-2004	52,032.7%
Xcel Brands (XELB)	1999-2004	28,400%
Oramed Pharmaceuticals (ORMP)	1999-2004	8,275.95%
First Majestic Silver (AG)	1999-2004	7,268.44%
Axon Enterprise (AXON)	1999-2004	5,326.02%
TherapeuticsMD (TXMD)	1999-2004	4,950.01%
China Yuchai International (CYD)	1999-2004	3,117.45%
Companhia Siderurgica Nacional ADR (SID)	1999-2004	2,747.45%
Oragenics (OGEN)	1999-2004	2,267.42%
American Vanguard (AVD)	1999-2004	2,234.58%
Versus Systems Inc. (VS)	1999-2004	2,200%
Quantum (QMCO)	1999-2004	2,191.09%
Deckers Outdoor (DECK)	1999-2004	2,110.5%
Sono-Tek (SOTK)	1999-2004	2,076.92%
Innodata (INOD)	1999-2004	1,770.72%
Inuvo (INUV)	1999-2004	1,728.71%
Cheniere Energy (LNG)	1999-2004	1,709.69%
Meritage (MTH)	1999-2004	1,694.28%