Inseego (INSG) had the highest return between 2000 and 2000 by a US stock, returning 3,093,650%.

ASSET	YEARS	% RETURN
Inseego (INSG)	2000-2000	3,093,650%
AlphaTON Capital (ATON)	2000-2000	58,013.21%
Live Ventures (LIVE)	2000-2000	4,365.63%
Sanara Medtech (SMTI)	2000-2000	650%
Flexible Solutions International (FSI)	2000-2000	472.41%
FuelCell Energy (FCEL)	2000-2000	452.64%
Manhattan Associates (MANH)	2000-2000	452.23%
Comstock Resources (CRK)	2000-2000	402.13%
374Water Inc Common Stock (SCWO)	2000-2000	400%
Laboratory Corporation of America (LH)	2000-2000	377.24%
Quest Diagnostics (DGX)	2000-2000	360.85%
CVD Equipment (CVV)	2000-2000	342.86%
Vertex Pharmaceuticals (VRTX)	2000-2000	302.82%
Artivion (AORT)	2000-2000	286.17%
RadNet (RDNT)	2000-2000	264.71%
Myriad Genetics (MYGN)	2000-2000	258.32%
Meritage (MTH)	2000-2000	246.52%
Mednax (MD)	2000-2000	243.75%
Avadel Pharmaceuticals (AVDL)	2000-2000	241.18%
CoreSite Realty (COR)	2000-2000	225.82%
XOMA (XOMA)	2000-2000	221.65%
EOG Resources (EOG)	2000-2000	219.42%
Everest (EG)	2000-2000	216.03%
Hallador Energy (HNRG)	2000-2000	214.24%
Waters (WAT)	2000-2000	213.62%