NVIDIA (NVDA) had the highest return between 2022 and 2024 by a mega-cap US stock, returning 351.1%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2022-2024	351.13%
Palantir Technologies Inc Class A Common Stock (PLTR)	2022-2024	311.93%
Broadcom (AVGO)	2022-2024	272.22%
Eli Lilly and (LLY)	2022-2024	189.83%
GE Aerospace (GE)	2022-2024	185.08%
Oracle (ORCL)	2022-2024	99.49%
Walmart (WMT)	2022-2024	96.43%
HSBC Holdings PLC ADR (HSBC)	2022-2024	95.93%
Exxon Mobil (XOM)	2022-2024	95.35%
T-Mobile US (TMUS)	2022-2024	94.34%
American Express (AXP)	2022-2024	87.67%
International Business Machines (IBM)	2022-2024	87.17%
SAP SE ADR (SAP)	2022-2024	85.92%
Caterpillar (CAT)	2022-2024	85.68%
Facebook (META)	2022-2024	73.74%
Costco Wholesale (COST)	2022-2024	69.21%
Taiwan Semiconductor Manufacturing (TSM)	2022-2024	68.04%
JPMorgan Chase (JPM)	2022-2024	63.1%
Novo Nordisk A-S (NVO)	2022-2024	63.08%
Shell PLC ADR (SHEL)	2022-2024	59.7%
Goldman Sachs (GS)	2022-2024	59.66%
Wells Fargo (WFC)	2022-2024	55.53%
Berkshire Hathaway (BRK.B)	2022-2024	51.04%
Berkshire Hathaway (BRK.A)	2022-2024	50.64%
Mastercard (MA)	2022-2024	48.97%

Mega-cap stocks are treated as having a market cap of $200B+.