Netflix (NFLX) had the highest return between 2012 and 2019 by a US stock in the S&P 500 (GSPC), returning 3,122.8%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2012-2019	3,122.81%
DexCom (DXCM)	2012-2019	2,197.69%
Texas Pacific Land Trust (TPL)	2012-2019	1,937.29%
NVIDIA (NVDA)	2012-2019	1,686.79%
EPAM Systems (EPAM)	2012-2019	1,442.98%
Paycom Soft (PAYC)	2012-2019	1,379.1%
Tesla (TSLA)	2012-2019	1,345.53%
Axon Enterprise (AXON)	2012-2019	1,298.47%
Monolithic Power Systems (MPWR)	2012-2019	1,186.93%
Broadcom (AVGO)	2012-2019	1,171.66%
Builders FirstSource (BLDR)	2012-2019	1,110%
ServiceNow (NOW)	2012-2019	1,088.72%
Align Technology (ALGN)	2012-2019	1,051.16%
Adobe Systems (ADBE)	2012-2019	1,049.16%
Transdigm (TDG)	2012-2019	996.19%
Amazon (AMZN)	2012-2019	950.57%
Fair Isaac (FICO)	2012-2019	919.38%
Frank's International (FI)	2012-2019	903.73%
Domino's Pizza Inc Common Stock (DPZ)	2012-2019	890.84%
Tyler Technologies (TYL)	2012-2019	871.88%
Corpay (CPAY)	2012-2019	860.03%
Constellation Brands Inc Class A (STZ)	2012-2019	857.74%
Trade Desk (TTD)	2012-2019	803.58%
Insulet (PODD)	2012-2019	790.74%
Take-Two Interactive Software (TTWO)	2012-2019	785.25%