Brera Holdings PLC Class B Ordinary Shares (BREA) had the highest return between 2021 and 2024 by a US stock, returning 1,645,900%.

ASSET	YEARS	% RETURN
Brera Holdings PLC Class B Ordinary Shares (BREA)	2021-2024	1,645,900%
DevvStream Corp Common Stock (DEVS)	2021-2024	751,900%
NioCorp Developments Ltd Common Stock (NB)	2021-2024	258,233.33%
MDxHealth SA ADR (MDXH)	2021-2024	215,354.55%
BioNexus Gene Lab Corp Common stock (BGLC)	2021-2024	121,639.13%
ReShape Lifesciences (RSLS)	2021-2024	10,152.87%
Azitra (AZTR)	2021-2024	7,507.14%
Trump Media & Technology (DJTWW)	2021-2024	4,092.87%
Applied Digital (APLD)	2021-2024	3,295.56%
CID HoldCo, Inc Warrants (DAICW)	2021-2024	2,400%
Wearable Devices (WLDSW)	2021-2024	2,287.01%
Zivo Bioscience (ZIVO)	2021-2024	2,257.46%
Castellum (CTM)	2021-2024	2,172.73%
Cresud SACIF y A Warrant (CRESW)	2021-2024	2,060%
Vista Oil Gas ADR (VIST)	2021-2024	1,989.19%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	2021-2024	1,793%
Alpha Metallurgical Resources (AMR)	2021-2024	1,757.33%
SoundHound AI (SOUNW)	2021-2024	1,604.01%
TSS, Inc Common Stock (TSSI)	2021-2024	1,535.86%
MicroCloud Hologram (HOLO)	2021-2024	1,329.16%
NewAmsterdam Pharma Company NV Warrant (NAMSW)	2021-2024	1,325%
Kolibri Global Energy Inc Common stock (KGEI)	2021-2024	1,230%
Nova Minerals Limited Warrant (NVAWW)	2021-2024	1,220%
Energy Services Of America (ESOA)	2021-2024	1,185.31%
Build-A-Bear Workshop (BBW)	2021-2024	1,121.6%