InterContinental Hotels Group PLC ADR (IHG) had the highest return between 1999 and 2003 by a US stock, returning 5,929,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	1999-2003	5,929,900%
Hirequest (HQI)	1999-2003	5,833,550%
Houston American Energy (HUSA)	1999-2003	188,874.84%
ImmunoPrecise Antibodies (HYFT)	1999-2003	122,042.86%
Flexible Solutions International (FSI)	1999-2003	81,262.75%
China Yuchai International (CYD)	1999-2003	7,113.58%
Versus Systems Inc. (VS)	1999-2003	3,900%
TherapeuticsMD (TXMD)	1999-2003	3,650%
Xcel Brands (XELB)	1999-2003	3,400%
Empire Petroleum (EP)	1999-2003	2,076.2%
Tandy Leather Factory (TLF)	1999-2003	1,837.74%
KVH Industries (KVHI)	1999-2003	1,817.98%
Companhia Siderurgica Nacional ADR (SID)	1999-2003	1,755.47%
OPTIMIZERx (OPRX)	1999-2003	1,600%
FTI Consulting (FCN)	1999-2003	1,487.42%
American Vanguard (AVD)	1999-2003	1,478.12%
SunOpta (STKL)	1999-2003	1,376.8%
SSR Mining (SSRM)	1999-2003	1,222.64%
Future Fintech (FTFT)	1999-2003	1,200%
John B Sanfilippo & Son (JBSS)	1999-2003	1,100.93%
Axon Enterprise (AXON)	1999-2003	1,076.79%
Laboratory Corporation of America (LH)	1999-2003	975%
Perdoceo Education (PRDO)	1999-2003	960.08%
Meritage (MTH)	1999-2003	955.71%
Middleby (MIDD)	1999-2003	937.33%