best performing stocks with a $5b+ market cap from jan 2022 to now

QMMM Holdings Limited Ordinary Shares (QMMM) has had the highest return between January 1, 2022 and October 10, 2025 by a US stock with a market cap of $5B+, returning 3,880%.

ASSET DATE % RETURN
QMMM Holdings Limited Ordinary Shares (QMMM)
1/1/2022 - 10/10/2025
3,880%
Celestica (CLS)
1/1/2022 - 10/10/2025
2,231.96%
Regencell Bioscience (RGC)
1/1/2022 - 10/10/2025
1,996.65%
Verona Pharma PLC ADR (VRNA)
1/1/2022 - 10/10/2025
1,474.52%
Modine Manufacturing (MOD)
1/1/2022 - 10/10/2025
1,357.09%
Oklo (OKLO)
1/1/2022 - 10/10/2025
1,300.91%
Sterling Construction (STRL)
1/1/2022 - 10/10/2025
1,239.1%
Super Micro Computer (SMCI)
1/1/2022 - 10/10/2025
1,199.71%
Credo Technology (CRDO)
1/1/2022 - 10/10/2025
1,149.17%
Ast Spacemobile (ASTS)
1/1/2022 - 10/10/2025
982.17%
Constellation Energy (CEG)
1/1/2022 - 10/10/2025
941.78%
Palantir Technologies Inc Class A Common Stock (PLTR)
1/1/2022 - 10/10/2025
910.19%
Rhythm Pharmaceuticals (RYTM)
1/1/2022 - 10/10/2025
902.1%
Vistra Energy (VST)
1/1/2022 - 10/10/2025
889.67%
Carpenter Technology (CRS)
1/1/2022 - 10/10/2025
793.19%
Hims Hers Health (HIMS)
1/1/2022 - 10/10/2025
785.26%
Summit Therapeutics (SMMT)
1/1/2022 - 10/10/2025
774.18%
Comfort Systems USA (FIX)
1/1/2022 - 10/10/2025
753.81%
Robinhood Markets (HOOD)
1/1/2022 - 10/10/2025
744.65%
Abivax SA American Depositary Shares (ABVX)
1/1/2022 - 10/10/2025
681.12%
Fortress Transp & Infra Inv (FTAI)
1/1/2022 - 10/10/2025
677.08%
IES (IESC)
1/1/2022 - 10/10/2025
674.11%
Centrus Energy (LEU)
1/1/2022 - 10/10/2025
621.96%
Flex (FLEX)
1/1/2022 - 10/10/2025
612.2%
Applied Digital (APLD)
1/1/2022 - 10/10/2025
599.11%