SharonAI Holdings, Inc Class A Common Stock (SHAZ) has had the highest return since January 21, 2025 by a small-cap US stock, returning 256,709.5%.

ASSET	% RETURN
SharonAI Holdings, Inc Class A Common Stock (SHAZ)	256,709.52%
Seaport Therapeutics, Inc Common Stock (SPTX)	168,000%
Mega Fortune Company Limited Ordinary Shares (MGRT)	3,212.28%
Relmada Therapeutics (RLMD)	1,780.11%
XMax (XWIN)	1,207.94%
Roma Green Finance Limited Ordinary Shares (ROMA)	1,198.39%
Santacruz Silver Mining Ltd Common Shares (SCZM)	946.18%
Udemy (UDMY)	907.59%
Palvella Therapeutics (PVLA)	765.45%
Inhibrx Biosciences (INBX)	688.39%
Oncology Institute (TOI)	586.21%
Adlai Nortye Ltd American Depositary Shares (ANL)	549.52%
Charming Medical Limited Class A Ordinary Shares (MCTA)	539.54%
Sellas Life Sciences (SLS)	532.14%
Avino Silver & Gold Mines (ASM)	531.86%
Everspin Technologies (MRAM)	485.2%
AnaptysBio (ANAB)	482.2%
Shattuck Labs (STTK)	458.93%
Climb Bio (CLYM)	445.45%
BUUU Group Limited Class A Ordinary Share (BUUU)	425%
Sify Technologies (SIFY)	424.33%
Anbio Biotechnology Class A Ordinary Shares (NNNN)	412.17%
United States Antimony (UAMY)	397.69%
Alto Neuroscience (ANRO)	395.26%
International Tower Hill Mines (THM)	390.25%

Small-cap stocks are treated as having a market cap between $300M and $2B.