WhiteHawk Minerals (WHK) has had the highest return since January 21, 2025 by a small-cap US stock, returning 430,233.3%.

ASSET	% RETURN
WhiteHawk Minerals (WHK)	430,233.33%
Seaport Therapeutics, Inc Common Stock (SPTX)	209,900%
Mega Fortune Company Limited Ordinary Shares (MGRT)	2,055.14%
Roma Green Finance Limited Ordinary Shares (ROMA)	1,440.32%
Relmada Therapeutics (RLMD)	1,344.14%
XMax (XMAX)	1,268.25%
XMax (XWIN)	1,265.08%
Nanobiotix (NBTX)	1,069.73%
Hycroft Mining (HYMC)	859.26%
Oncology Institute (TOI)	836.21%
Santacruz Silver Mining Ltd Common Shares (SCZM)	688.84%
Goldgroup Mining (GORO)	677.34%
Babcock & Wilcox Enterprises (BW)	570.37%
Phoenix Asia Holdings Limited Ordinary Shares (PHOE)	565%
Climb Bio (CLYM)	561.62%
Shattuck Labs (STTK)	543.75%
Charming Medical Limited Class A Ordinary Shares (MCTA)	539.54%
Inhibrx Biosciences (INBX)	535.78%
Adlai Nortye Ltd American Depositary Shares (ANL)	525%
Alto Neuroscience (ANRO)	483.41%
Amylyx Pharmaceuticals (AMLX)	439.36%
Avino Silver & Gold Mines (ASM)	435.4%
BUUU Group Limited Class A Ordinary Share (BUUU)	406.25%
Entravision Communications (EVC)	401.36%
AnaptysBio (ANAB)	395.63%

Small-cap stocks are treated as having a market cap between $300M and $2B.