Wolfspeed (WOLF) had the highest return last month by a small-cap US stock, returning 2,263.6%.

ASSET	MONTH	% RETURN
Wolfspeed (WOLF)	September 2025	2,263.64%
Eos Energy Enterprises (EOSEW)	September 2025	365.79%
Bakkt (BKKT)	September 2025	295.42%
PepGen (PEPG)	September 2025	294.87%
Mercurity Fintech Holding Inc ADR (MFH)	September 2025	284.66%
Helius Medical Technologies Inc Class A (HSDT)	September 2025	157.61%
Better Home & Finance (BETR)	September 2025	154.26%
Mobilicom Limited Warrants (MOBBW)	September 2025	152.33%
Monopar Therapeutics (MNPR)	September 2025	149.22%
RAPT Therapeutics (RAPT)	September 2025	128.23%
Nanobiotix (NBTX)	September 2025	127.86%
Clearpoint Neuro (CLPT)	September 2025	111.76%
Frequency Therapeutics (KRRO)	September 2025	111.06%
Tourmaline Bio (TRML)	September 2025	105.63%
American Battery Technology Company Common Stock (ABAT)	September 2025	100.83%
Nektar Therapeutics (NKTR)	September 2025	96.14%
Lithium Americas (LAC)	September 2025	95.55%
Diginex Limited Ordinary Shares (DGNX)	September 2025	92.02%
Vimeo (VMEO)	September 2025	87.2%
Kodiak Sciences (KOD)	September 2025	84.97%
GDEV (GDEV)	September 2025	82.45%
Olema Pharmaceuticals (OLMA)	September 2025	78.65%
Anywhere Real Estate (HOUS)	September 2025	77.98%
Maze Therapeutics, Inc Common Stock (MAZE)	September 2025	77.12%
Prime Medicine, Inc Common Stock (PRME)	September 2025	74.76%

Small-cap stocks are treated as having a market cap between $300M and $2B.