Diginex Limited Ordinary Shares (DGNX) has had the highest return this year by a small-cap US stock, returning 4,581.7%.

ASSET	YEAR	% RETURN
Diginex Limited Ordinary Shares (DGNX)	2025	4,581.69%
DeFi Development (DFDV)	2025	2,234.67%
Zepp Health (ZEPP)	2025	1,768.08%
Oncology Institute (TOI)	2025	1,138.56%
Nanobiotix (NBTX)	2025	658.84%
Airnet Technology (ANTE)	2025	627.88%
United States Antimony (UAMY)	2025	585.96%
NioCorp Developments Ltd Common Stock (NB)	2025	553.46%
Better Home & Finance (BETR)	2025	521.41%
ThredUp (TDUP)	2025	499.31%
Mobilicom Limited Warrants (MOBBW)	2025	480.21%
Newegg Commerce (NEGG)	2025	477.38%
Sify Technologies (SIFY)	2025	476.92%
IsoEnergy (ISOU)	2025	465.24%
I-Mab (IMAB)	2025	461.18%
Avino Silver & Gold Mines (ASM)	2025	452.75%
Trilogy Metals (TMQ)	2025	411.21%
Wolfspeed (WOLF)	2025	358.03%
DBV Technologies (DBVT)	2025	355.93%
American Resources Corp Class A (AREC)	2025	353.33%
Lightbridge (LTBR)	2025	346.96%
Americas Silver (USAS)	2025	333.37%
So-Young International (SY)	2025	330.34%
International Tower Hill Mines (THM)	2025	327.33%
Village Farms International (VFF)	2025	326.55%

Small-cap stocks are treated as having a market cap between $300M and $2B.