Palatin Technologies (PTNT) had the highest return in September 2025 by a US stock, returning 3,858.4%.

ASSET	MONTH	% RETURN
Palatin Technologies (PTNT)	September 2025	3,858.35%
QMMM Holdings Limited Ordinary Shares (QMMM)	September 2025	2,361.86%
Wolfspeed (WOLF)	September 2025	2,263.64%
Pitanium (PTNM)	September 2025	527.18%
Eightco (ORBS)	September 2025	518.24%
Arqit Quantum Inc Warrants (ARQQW)	September 2025	452.94%
Soluna (SLNH)	September 2025	385.54%
New Era Energy & Digital (NUAIW)	September 2025	382.53%
Apollomics Inc Class A Ordinary Shares (APLM)	September 2025	367.84%
Brera (SLMT)	September 2025	361.04%
Brera Holdings PLC Class B Ordinary Shares (BREA)	September 2025	361.04%
Wearable Devices (WLDS)	September 2025	350.93%
AGM Group Holdings Inc Class A (AGMH)	September 2025	324.49%
New Era Energy & Digital (NUAI)	September 2025	309.8%
Bakkt (BKKT)	September 2025	295.42%
PepGen (PEPG)	September 2025	294.87%
Mercurity Fintech Holding Inc ADR (MFH)	September 2025	284.66%
Uniqure (QURE)	September 2025	258.54%
Platinum Analytics Cayman Limited Class A Ordinary Shares (PLTS)	September 2025	243.26%
Boqii (BQ)	September 2025	243.16%
Datavault AI (DVLT)	September 2025	220.59%
XMax (XWIN)	September 2025	214.86%
Skyline Builders Group Holding Limited Class A Ordinary Shares (SKBL)	September 2025	208.11%
Check-Cap (CHEK)	September 2025	207.25%
OneMedNet (ONMDW)	September 2025	188.95%