Netflix (NFLX) had the highest return between 2008 and 2010 by a large-cap US stock or large-cap US stock, returning 561.6%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2008-2010	561.57%
F5 Networks (FFIV)	2008-2010	364.53%
Edwards Lifesciences (EW)	2008-2010	253.63%
Booking (BKNG)	2008-2010	242.23%
Skyworks Solutions (SWKS)	2008-2010	238.02%
Nova (NVMI)	2008-2010	233.73%
Alamos Gold (AGI)	2008-2010	232.24%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2008-2010	228.12%
Dollar Tree (DLTR)	2008-2010	224.54%
Flutter Entertainment (FLUT)	2008-2010	184.34%
Tractor Supply (TSCO)	2008-2010	173.96%
Ross Stores (ROST)	2008-2010	157.17%
Ford Motor (F)	2008-2010	149.48%
Baidu (BIDU)	2008-2010	144.69%
XPO Logistics (XPO)	2008-2010	132.75%
Banco De Chile (BCH)	2008-2010	131.18%
AutoZone (AZO)	2008-2010	126.97%
Wheaton Precious Metals (WPM)	2008-2010	126.58%
Franco-Nevada (FNV)	2008-2010	123.92%
NetApp (NTAP)	2008-2010	118.88%
Ambev SA ADR (ABEV)	2008-2010	118.38%
Cognizant Technology Solutions Corp Class A (CTSH)	2008-2010	116.64%
Ecopetrol SA ADR (EC)	2008-2010	114.38%
Dillard's (DDS)	2008-2010	112.84%
Banco Santander Chile (BSAC)	2008-2010	111.95%

Large-cap stocks are treated as having a market cap of $10B+.