QXO (QXO) had the highest return between 2009 and 2022 by a US stock, returning 4,685,225%.

ASSET	YEARS	% RETURN
QXO (QXO)	2009-2022	4,685,225%
BioNexus Gene Lab Corp Common stock (BGLC)	2009-2022	2,780,387.8%
KULR Technology (KULR)	2009-2022	2,399,900%
Next Technology (NXTT)	2009-2022	1,162,346.87%
Sequans Communications (SQNS)	2009-2022	999,900%
MDxHealth SA ADR (MDXH)	2009-2022	734,344.44%
Connexa Sports Technologies (YYAI)	2009-2022	467,900%
Heart Test Laboratories Inc Common Stock (HSCS)	2009-2022	246,958.82%
AquaBounty Technologies (AQB)	2009-2022	212,122.22%
Immatics (IMTX)	2009-2022	174,100%
Iqstel (IQST)	2009-2022	146,895.96%
Eastside Distilling (BLNE)	2009-2022	137,437.54%
GeoVax Labs (GOVX)	2009-2022	134,900%
Integra Resources (ITRG)	2009-2022	126,500%
Aurora Cannabis (ACB)	2009-2022	122,966.67%
Blackboxstocks (BLBX)	2009-2022	70,488.24%
GT Biopharma (GTBP)	2009-2022	66,350%
Xpel (XPEL)	2009-2022	57,100%
Nexstar Broadcasting (NXST)	2009-2022	31,541.43%
TCTM Kids IT Education (VSA)	2009-2022	30,555.11%
Metalla Royalty & Streaming (MTA)	2009-2022	29,328.31%
ACCESS Newswire (ACCS)	2009-2022	27,908.95%
Processa Pharmaceuticals (PCSA)	2009-2022	26,090.48%
Guardforce AI (GFAI)	2009-2022	24,323.08%
Avis Budget (CAR)	2009-2022	22,987.92%