InspireMD (NSPR) had the lowest return between 2016 and 2021 by a US stock, returning -100%.

ASSET	YEARS	% RETURN
InspireMD (NSPR)	2016-2021	-100%
Golden Matrix (GMGI)	2016-2021	-100%
Aytu BioScience (AYTU)	2016-2021	-100%
MetroCity Bankshares (MCBS)	2016-2021	-100%
Creative Medical Technology (CELZ)	2016-2021	-99.99%
Performance Shipping (PSHG)	2016-2021	-99.99%
Sellas Life Sciences (SLS)	2016-2021	-99.99%
Iqstel (IQST)	2016-2021	-99.98%
TOP Ships (TOPS)	2016-2021	-99.98%
BioRestorative Therapies (BRTX)	2016-2021	-99.97%
Nextplat (NXPL)	2016-2021	-99.97%
Phio Pharmaceuticals (PHIO)	2016-2021	-99.95%
SS Innovations International Inc Common Stock (SSII)	2016-2021	-99.95%
Cenntro Electric (CENN)	2016-2021	-99.95%
Plus Therapeutics (PSTV)	2016-2021	-99.93%
Palisade Bio (PALI)	2016-2021	-99.9%
Traws Pharma (TRAW)	2016-2021	-99.88%
Seanergy Maritime (SHIP)	2016-2021	-99.87%
Predictive Oncology (POAI)	2016-2021	-99.87%
Sonnet Biotherapeutics (SONN)	2016-2021	-99.84%
Synergy CHC Corp Common Stock (SNYR)	2016-2021	-99.84%
BTCS (BTCS)	2016-2021	-99.84%
Salarius Pharmaceuticals (SLRX)	2016-2021	-99.83%
CervoMed (CRVO)	2016-2021	-99.8%
Tempest Therapeutics (TPST)	2016-2021	-99.75%