Itau Unibanco Banco (ITUB) had the lowest return between 2000 and 2025 by a large-cap US stock, returning -100%.

ASSET	YEARS	% RETURN
Itau Unibanco Banco (ITUB)	2000-2025	-100%
Banco Bradesco SA ADR (BBD)	2000-2025	-99.98%
Galaxy Digital (GLXY)	2000-2025	-96.69%
TechnipFMC (FTI)	2000-2025	-95.81%
Viavi Solutions (VIAV)	2000-2025	-95.74%
Immunitybio (IBRX)	2000-2025	-94.65%
Ferrovial SE (FER)	2000-2025	-93.21%
American International (AIG)	2000-2025	-89.83%
Natwest (NWG)	2000-2025	-84.64%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	2000-2025	-78.32%
Globalstar, Inc Common Stock (GSAT)	2000-2025	-76.08%
Rivian Automotive (RIVN)	2000-2025	-74.73%
Akamai Technologies (AKAM)	2000-2025	-74.65%
Nokia (NOK)	2000-2025	-72.19%
10X Genomics (TXG)	2000-2025	-69.8%
Snap (SNAP)	2000-2025	-66.38%
Coupang LLC (CPNG)	2000-2025	-62.85%
Aurora Innovation (AUR)	2000-2025	-61.6%
Oscar Health (OSCR)	2000-2025	-60.08%
Grab (GRAB)	2000-2025	-58.03%
Skydance (SKYD)	2000-2025	-52.72%
Banco Bradesco S/A ADR (BBDO)	2000-2025	-52.53%
Ke Holdings (BEKE)	2000-2025	-52.45%
Aegon NV ADR (AEG)	2000-2025	-49.38%
Coeur Mining (CDE)	2000-2025	-49.06%

Large-cap stocks are treated as having a market cap of $10B+.