Alnylam Pharmaceuticals (ALNY) had the lowest return on January 11, 2017 by a large-cap US stock, returning -7.3%.

ASSET	DATE	% RETURN
Alnylam Pharmaceuticals (ALNY)	1/11/2017	-7.32%
Natera (NTRA)	1/11/2017	-6.76%
United Therapeutics (UTHR)	1/11/2017	-5.98%
Viatris (VTRS)	1/11/2017	-5.74%
Fabrinet (FN)	1/11/2017	-5.03%
CoreSite Realty (COR)	1/11/2017	-4.25%
Biomarin Pharmaceutical (BMRN)	1/11/2017	-4.2%
Neurocrine Biosciences (NBIX)	1/11/2017	-4.17%
Exelixis (EXEL)	1/11/2017	-3.6%
AbbVie (ABBV)	1/11/2017	-3.53%
Equinox Gold (EQX)	1/11/2017	-3.47%
Biogen (BIIB)	1/11/2017	-3.31%
Incyte (INCY)	1/11/2017	-2.95%
Summit Therapeutics (SMMT)	1/11/2017	-2.86%
Ionis Pharmaceuticals (IONS)	1/11/2017	-2.72%
Bio-Techne (TECH)	1/11/2017	-2.6%
Teva Pharma Industries Ltd ADR (TEVA)	1/11/2017	-2.5%
Pure Storage (PSTG)	1/11/2017	-2.42%
Gilead Sciences (GILD)	1/11/2017	-2.32%
Bristol-Myers Squibb (BMY)	1/11/2017	-2.27%
McKesson (MCK)	1/11/2017	-2.25%
Gildan Activewear (GIL)	1/11/2017	-2.23%
Dr Reddy’s Laboratories Ltd ADR (RDY)	1/11/2017	-2.19%
Grupo Aeroportuario del Pacifico SAB De CV ADR (PAC)	1/11/2017	-2.19%
Lumentum (LITE)	1/11/2017	-2.14%

Large-cap stocks are treated as having a market cap of $10B+.