Answered April 30th, 2019

Brandon Marshall has 21 receptions at Indianapolis, breaking Terrell Owens' NFL single-game record set in 2000.

Who has the most receptions in a game?
Interpreted as:
Who has the most receptions in a regular season game?
12/13/2009Marshall12/17/2000Owens10/28/2012Witten9/14/2008Marshall12/3/1950Fears11/8/2015Brown9/21/1980Gaines9/9/2018Thomas12/20/2015Brown9/25/2011Welker9/22/2002Brown10/20/1996McCardell11/20/1994Rice11/4/1962Randle9/23/2018Kamara9/13/2015Allen12/20/2014Ertz9/16/2012Amendola10/3/2010Wayne11/22/2009Welker2120181818171716161616161616151515151515
NAMEDATETMOPPRECTRGREC YDSREC AVGREC TDRUSH YDSATTRUSH AVGRUSH TD
Brandon MarshallBrandon Marshall12/13/2009DENDEN@ IND
@
21282009.52000
Terrell OwensTerrell Owens12/17/2000SFSFvs. CHI
vs.
202228314.21515.00
Jason WittenJason Witten10/28/2012DALDALvs. NYG
vs.
18231679.30000
Brandon MarshallBrandon Marshall9/14/2008DENDENvs. SD
vs.
18201669.21000
Tom FearsTom Fears12/3/1950LALAvs. GB
vs.
1818910.52
Antonio BrownAntonio Brown11/8/2015PITPITvs. OAK
vs.
172328416.7022211.00
Clark GainesClark Gaines9/21/1980NYJNYJvs. SF
vs.
171609.402054.00
Michael ThomasMichael Thomas9/9/2018NONOvs. TB
vs.
161718011.31000
Antonio BrownAntonio Brown12/20/2015PITPITvs. DEN
vs.
161818911.82000
Wes WelkerWes Welker9/25/2011NENE@ BUF
@
162021713.6219119.00
Troy BrownTroy Brown9/22/2002NENEvs. KC
vs.
162117611.01000
Keenan McCardellKeenan McCardell10/20/1996JAXJAX@ STL
@
1623214.50000
Jerry RiceJerry Rice11/20/1994SFSFvs. RAM
vs.
1616510.33313.00
Sonny RandleSonny Randle11/4/1962STLSTL@ NYG
@
1625616.01000
Alvin KamaraAlvin Kamara9/23/2018NONO@ ATL
@
15201248.3066164.10
Keenan AllenKeenan Allen9/13/2015SDSDvs. DET
vs.
151716611.10000
Zach ErtzZach Ertz12/20/2014PHIPHI@ WAS
@
15181157.70000
Danny AmendolaDanny Amendola9/16/2012STLSTLvs. WAS
vs.
151616010.71000
Reggie WayneReggie Wayne10/3/2010INDIND@ JAX
@
151919613.10000
Wes WelkerWes Welker11/22/2009NENEvs. NYJ
vs.
151719212.8011111.00
Jason WittenJason Witten12/9/2007DALDAL@ DET
@
15181389.21000
Chris ChambersChris Chambers12/4/2005MIAMIAvs. BUF
vs.
152623815.91000
Jimmy SmithJimmy Smith9/10/2000JAXJAX@ BAL
@
152129119.43000
Isaac BruceIsaac Bruce12/24/1995STLSTLvs. MIA
vs.
1521014.0112112.00
Andre ReedAndre Reed11/20/1994BUFBUFvs. GB
vs.
1519112.72414.00
Results may be incomplete. StatMuse has complete game-level data for receptions going back to the 1960 season.