The Denver Nuggets and the Minneapolis Lakers are tied for the highest point differential in a playoff game, with a 58 point differential.

largest nba postseason single game point differential

TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
Nuggets	58	4/27/2009	DEN	@	NOH	W 121-63	240	121	41	29	15	6	43	76	56.6	10	20	50.0	25	30	83.3	67.8	10	31	11	29
Lakers	58	3/19/1956	MIN	vs	STL	W 133-75	240	133					44	101	43.6				45	53	84.9	53.5				30
Lakers	56	4/21/1973	LAL	@	GSW	W 126-70	240	126	75	31			51	109	46.8				24	31	77.4	51.4				12
Bulls	54	4/30/2015	CHI	@	MIL	W 120-66	240	120	50	31	7	2	46	90	51.1	15	30	50.0	13	16	81.3	61.8	10	40	12	14
Bucks	50	4/4/1971	MIL	vs	SFW	W 136-86	240	136	56	37			58	104	55.8				20	28	71.4	58.5				26
Magic	47	4/28/1995	ORL	vs	BOS	W 124-77	240	124	50	27	11	7	42	86	48.8	9	17	52.9	31	37	83.8	60.6	18	32	13	25
Lakers	47	4/17/1986	LAL	vs	SAS	W 135-88	240	135	47	38	15	8	57	86	66.3	1	4	25.0	20	22	90.9	70.5	11	36	23	22
Timberwolves	45	5/16/2024	MIN	vs	DEN	W 115-70	240	115	62	26	9	4	40	86	46.5	15	40	37.5	20	24	83.3	59.5	11	51	6	14
Cavaliers	44	5/19/2017	CLE	@	BOS	W 130-86	240	130	45	28	10	6	48	85	56.5	19	39	48.7	15	23	65.2	68.3	9	36	12	17
SuperSonics	44	4/27/1997	SEA	vs	PHX	W 122-78	240	122	50	24	14	9	45	92	48.9	9	28	32.1	23	30	76.7	58.0	14	36	12	30
Lakers	44	5/22/1985	LAL	vs	DEN	W 153-109	240	153	54	42	13	13	67	116	57.8	1	4	25.0	18	21	85.7	61.1	17	37	12	23
Hawks	44	3/25/1958	STL	@	DET	W 145-101	240	145					55	98	56.1				35	44	79.5	61.8				29
Clippers	43	8/25/2020	LAC	vs	DAL	W 154-111	240	154	49	28	5	4	53	84	63.1	22	35	62.9	26	34	76.5	77.8	8	41	15	26
Magic	43	5/4/2010	ORL	vs	ATL	W 114-71	240	114	53	23	6	7	44	84	52.4	9	23	39.1	17	24	70.8	60.3	14	39	13	17
Pistons	43	4/26/1987	DET	vs	WAS	W 128-85	240	128	57	36	10	12	54	95	56.8	2	4	50.0	18	20	90.0	61.7	12	45	20	20
Lakers	43	4/28/1984	LAL	vs	DAL	W 134-91	240	134	43	32	11	11	51	85	60.0	2	2	100.0	30	37	81.1	66.2	10	33	16	26
Bulls	42	6/7/1998	CHI	vs	UTA	W 96-54	240	96	50	25	13	6	37	76	48.7	4	11	36.4	18	26	69.2	54.9	11	39	17	19
Warriors	41	5/20/2018	GSW	vs	HOU	W 126-85	240	126	49	20	11	7	48	92	52.2	13	32	40.6	17	18	94.4	63.1	11	38	8	16
Bulls	41	4/25/1991	CHI	vs	NYK	W 126-85	240	126	41	26	15	0	44	84	52.4	6	10	60.0	32	42	76.2	61.5	15	26	15	20
Lakers	40	4/28/2023	LAL	vs	MEM	W 125-85	240	125	52	33	6	15	49	91	53.8	15	44	34.1	12	15	80.0	64.0	9	43	13	16
Clippers	40	4/21/2014	LAC	vs	GSW	W 138-98	240	138	34	29	15	5	47	83	56.6	12	25	48.0	32	35	91.4	70.1	9	25	13	22
Lakers	40	5/12/2009	LAL	vs	HOU	W 118-78	240	118	49	20	12	7	42	82	51.2	6	13	46.2	28	36	77.8	60.3	12	37	12	18
Mavericks	40	5/7/2005	DAL	vs	HOU	W 116-76	240	116	52	21	7	10	41	80	51.3	8	16	50.0	26	28	92.9	62.8	16	36	13	19
Spurs	40	5/4/1983	SAS	vs	DEN	W 145-105	240	145	75	51	12	10	67	124	54.0	3	7	42.9	8	11	72.7	56.3	19	56	18	28
Celtics	40	5/9/1982	BOS	vs	PHI	W 121-81	240	121	67	34		11	51	110	46.4	0	3	0.0	19	27	70.4	49.6			13	28