Wilt Chamberlain had the most games with 5+ seasons and 50+ points, with 118 games.

Interpreted as:

most 50 or more point regular-season game by a player in 5 or more seasons

	NAME	GP	PTS	SEAS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	118	6,772	10		57.4	26.3				23.5	41.9	56.0				10.4	17.5	59.5	57.8					3,102					209
2	Michael Jordan M. Jordan	31	1,677	10	42.4	54.1	7.6	4.5	3.4	1.2	20.0	32.8	60.9	1.2	2.5	47.4	13.0	14.7	88.4	68.9	2.0	5.6	2.9	1,313	236	140	104	37	89	93	+40
3	Kobe Bryant K. Bryant	25	1,377	8	44.0	55.1	6.3	3.4	1.6	0.5	18.7	35.0	53.4	4.3	9.4	45.5	13.4	15.1	89.1	66.2	1.0	5.3	2.7	1,101	158	86	39	12	68	67	+285
4	James Harden J. Harden	24	1,307	7	40.2	54.5	7.8	8.2	2.1	0.6	16.0	30.2	53.1	6.6	14.5	45.7	15.8	17.4	90.4	71.9	1.5	6.3	5.5	964	186	197	51	15	131	75	+308
5	Elgin Baylor E. Baylor	17	930	5		54.7	18.6				20.5						13.8	17.6	78.0						317					64
6	Damian Lillard D. Lillard	15	826	7	39.4	55.1	4.4	7.4	1.4	0.2	17.0	29.4	57.8	7.7	14.5	53.5	13.3	14.1	94.3	77.3	0.5	3.9	2.4	590	66	111	21	3	36	22	+165
7	Stephen Curry S. Curry	15	801	9	36.9	53.4	5.5	5.5	1.7	0.4	17.4	28.3	61.6	9.9	16.5	59.7	8.7	9.2	94.9	82.6	0.4	5.1	3.4	553	83	83	25	6	51	26	+142
8	LeBron James L. James	14	744	9	42.5	53.1	7.9	7.1	1.5	0.9	18.4	30.6	59.9	5.2	9.3	56.2	11.2	13.9	80.5	72.3	1.4	6.4	3.2	595	110	99	21	12	45	31	+135
9	Rick Barry R. Barry	14	743	6	44.3	53.1	8.8	6.1	3.5		20.9	38.3	54.5				11.4	12.6	90.3	60.6	1.0	6.3	2.0	620	123	86	21		4	42
10	Allen Iverson A. Iverson	11	582	8	45.3	52.9	4.4	5.5	2.5	0.2	18.6	33.8	55.1	2.7	5.5	49.2	12.9	16.0	80.7	64.7	0.9	3.5	4.5	499	48	61	28	2	50	30	+69
11	Giannis Antetokounmpo G. Antetokounmpo	9	488	6	36.8	54.2	14.0	4.8	1.3	0.6	18.9	29.2	64.6	1.6	4.4	35.0	14.9	18.7	79.8	72.4	3.1	10.9	3.3	331	126	43	12	5	30	21	+126
12	Kevin Durant K. Durant	9	468	6	44.2	52.0	7.9	5.6	1.4	0.7	17.2	30.3	56.8	5.4	10.0	54.4	12.1	13.7	88.6	71.5	0.9	7.0	4.2	398	71	50	13	6	38	21	+55
13	Bob Pettit B. Pettit	6	313	5		52.2					20.5	34.0	60.3				11.2	14.2	78.8	64.8										18
14	Anthony Davis A. Davis	5	267	5	40.0	53.4	15.4	3.8	2.0	2.8	19.8	31.2	63.5	0.8	2.0	40.0	13.0	14.4	90.3	71.1	4.2	11.2	1.8	200	77	19	10	14	9	10	+59