I couldn't find anything for this season, but the Oklahoma City Thunder had their lowest point differential in a loss in 2025-26 against the Suns on April 12, with a -32 point differential.

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Regular season
2025-26 season

	TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Thunder	-32	4/12/2026	OKC	vs	PHX	L 103-135	240	103	36	32	9	7	41	95	43.2	18	46	39.1	3	9	33.3	52.0	9	27	10	8
2	Thunder	-27	1/5/2026	OKC	vs	CHA	L 97-124	240	97	33	18	14	5	34	93	36.6	11	39	28.2	18	27	66.7	46.2	13	20	8	14
3	Thunder	-20	4/10/2026	OKC	@	DEN	L 107-127	240	107	46	25	11	1	42	99	42.4	14	44	31.8	9	12	75.0	51.3	15	31	13	15
4	Thunder	-20	12/23/2025	OKC	@	SAS	L 110-130	240	110	36	23	5	1	46	85	54.1	12	30	40.0	6	7	85.7	62.4	9	27	15	17
5	Thunder	-17	2/12/2026	OKC	vs	MIL	L 93-110	240	93	47	22	3	6	31	83	37.3	15	45	33.3	16	20	80.0	50.7	14	33	16	8
6	Thunder	-15	12/25/2025	OKC	vs	SAS	L 102-117	240	102	48	23	7	6	37	95	38.9	11	44	25.0	17	25	68.0	48.1	16	32	7	18
7	Thunder	-12	1/29/2026	OKC	@	MIN	L 111-123	240	111	36	27	11	5	41	86	47.7	11	31	35.5	18	20	90.0	58.5	11	25	16	15
8	Thunder	-10	3/25/2026	OKC	@	BOS	L 109-119	240	109	35	17	7	3	38	80	47.5	12	37	32.4	21	26	80.8	59.6	4	31	7	22
9	Thunder	-10	2/4/2026	OKC	@	SAS	L 106-116	240	106	46	26	10	9	37	93	39.8	19	47	40.4	13	14	92.9	53.4	9	37	14	16
10	Thunder	-8	2/25/2026	OKC	@	DET	L 116-124	240	116	37	28	7	3	39	96	40.6	18	49	36.7	20	21	95.2	55.1	12	25	14	20
11	Thunder	-6	2/7/2026	OKC	vs	HOU	L 106-112	240	106	42	25	10	2	37	82	45.1	14	36	38.9	18	28	64.3	56.2	13	29	17	20
12	Thunder	-5	12/19/2025	OKC	@	MIN	L 107-112	240	107	52	16	7	10	34	92	37.0	11	39	28.2	28	30	93.3	50.9	13	39	12	30
13	Thunder	-3	1/23/2026	OKC	vs	IND	L 114-117	240	114	41	18	4	8	40	82	48.8	7	26	26.9	27	30	90.0	59.9	4	37	9	22
14	Thunder	-3	1/4/2026	OKC	@	PHX	L 105-108	240	105	29	20	2	4	39	82	47.6	10	32	31.3	17	19	89.5	58.1	2	27	9	20
15	Thunder	-2	1/25/2026	OKC	vs	TOR	L 101-103	240	101	37	21	5	5	33	75	44.0	11	43	25.6	24	31	77.4	57.0	5	32	11	17
16	Thunder	-2	1/17/2026	OKC	@	MIA	L 120-122	240	120	46	23	3	6	42	77	54.5	13	29	44.8	23	28	82.1	67.2	5	41	15	19
17	Thunder	-2	12/13/2025	OKC	vs	SAS	L 109-111	240	109	51	20	13	4	38	92	41.3	9	37	24.3	24	27	88.9	52.5	14	37	15	25
18	Thunder	-2	11/5/2025	OKC	@	POR	L 119-121	240	119	50	24	9	5	38	91	41.8	15	38	39.5	28	31	90.3	56.9	13	37	15	27