Kyle Lowry has the highest career plus/minus for the Raptors, at +2456.

NAME	+/-	GP	MPG	PPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF
Kyle Lowry	+2456	601	34.6	17.5	4.9	7.1	1.5	0.3	2.6	5.6	13.2	42.5	2.5	6.7	37.7	3.8	4.6	82.5	20,813	10,540	2,954	4,277	873	195	1,591	1,769
Pascal Siakam	+1755	510	31.0	17.4	6.5	3.6	0.9	0.6	1.9	6.6	13.4	49.1	1.0	3.2	32.7	3.2	4.1	77.2	15,786	8,875	3,324	1,846	468	317	965	1,400
Fred VanVleet	+1466	417	29.7	14.6	3.3	5.3	1.3	0.4	1.7	4.9	12.2	40.2	2.4	6.4	37.3	2.4	2.7	86.9	12,398	6,090	1,385	2,199	562	169	697	882
Patrick Patterson	+1203	273	25.2	7.6	4.8	1.4	0.7	0.5	0.8	2.8	6.5	43.5	1.3	3.4	37.3	0.6	0.8	76.9	6,893	2,073	1,311	388	195	133	206	517
OG Anunoby	+942	395	28.7	11.8	4.3	1.6	1.2	0.5	1.3	4.5	9.5	47.3	1.6	4.4	37.5	1.2	1.7	74.2	11,346	4,676	1,684	632	487	201	509	944
Serge Ibaka	+708	228	27.6	14.2	7.4	1.1	0.4	1.2	1.5	5.8	11.4	50.3	1.2	3.3	35.6	1.5	2.0	76.8	6,300	3,243	1,687	253	93	281	352	649
Danny Green	+638	80	27.7	10.3	4.0	1.6	0.9	0.7	0.9	3.7	7.9	46.5	2.5	5.4	45.5	0.5	0.6	84.1	2,216	821	317	126	73	53	75	171
Terrence Ross	+508	363	23.3	9.5	2.6	0.9	0.7	0.3	0.8	3.6	8.4	42.2	1.6	4.4	37.6	0.7	0.8	79.9	8,444	3,432	945	319	267	111	284	643
Jonas Valanciunas	+501	470	25.1	11.8	8.4	0.7	0.4	1.0	1.5	4.6	8.3	55.9	0.1	0.2	37.0	2.4	3.1	78.7	11,774	5,524	3,961	350	178	479	684	1,307
Marc Gasol	+476	70	25.8	8.1	6.4	3.5	0.8	0.9	1.4	2.9	6.7	44.2	1.1	2.9	40.0	1.1	1.4	75.2	1,809	568	447	248	58	61	95	194
Vince Carter	+473	403	37.5	23.4	5.2	3.9	1.3	1.0	2.3	8.8	19.7	44.6	1.4	3.6	38.3	4.4	5.7	78.3	15,114	9,420	2,091	1,553	534	415	928	1,188
Amir Johnson	+399	451	25.2	8.8	6.3	1.2	0.7	1.1	1.3	3.7	6.4	57.2	0.1	0.3	34.1	1.3	1.9	68.7	11,377	3,957	2,836	562	311	480	576	1,524
Anthony Parker	+391	235	32.8	11.9	4.0	2.6	1.1	0.2	1.2	4.4	9.7	46.0	1.5	3.4	42.4	1.5	1.8	82.9	7,708	2,785	934	605	252	43	272	437
Chris Boucher	+381	356	17.8	8.7	5.2	0.5	0.5	1.0	0.5	3.1	6.3	48.8	0.8	2.5	33.4	1.7	2.2	77.9	6,353	3,110	1,859	168	173	359	192	696
Kawhi Leonard	+356	60	34.0	26.6	7.3	3.3	1.8	0.4	2.0	9.3	18.8	49.6	1.9	5.0	37.1	6.1	7.1	85.4	2,040	1,596	439	199	106	24	121	87
Jakob Poeltl	+345	212	19.7	7.7	5.8	1.2	0.6	1.1	1.0	3.4	5.2	64.9	0.0	0.0	50.0	0.9	1.6	56.7	4,176	1,628	1,224	252	121	230	220	551
Cory Joseph	+317	160	25.3	8.9	2.8	3.2	0.8	0.2	1.3	3.5	7.8	44.6	0.5	1.5	31.8	1.4	1.9	76.7	4,049	1,417	445	515	129	33	210	271
Greivis Vasquez	+307	143	23.1	9.5	2.5	3.7	0.5	0.1	1.5	3.6	8.6	41.2	1.6	4.1	38.3	0.8	1.0	81.0	3,305	1,357	355	530	71	14	220	282
Delon Wright	+299	172	17.5	6.7	2.4	2.3	0.9	0.4	0.9	2.4	5.4	44.8	0.6	1.7	35.3	1.3	1.6	81.3	3,005	1,145	408	398	153	62	156	172
Lou Williams	+295	80	25.2	15.5	1.9	2.1	1.1	0.1	1.3	4.7	11.6	40.4	1.9	5.6	34.0	4.3	4.9	86.1	2,016	1,242	151	164	88	10	101	103
Jamario Moon	+295	132	26.9	8.0	5.6	1.2	1.1	1.2	0.6	3.3	6.8	48.1	0.6	1.8	33.6	0.9	1.1	78.7	3,545	1,054	733	160	145	152	82	237
Lucas Nogueira	+278	141	12.4	3.2	2.8	0.5	0.6	1.0	0.5	1.3	2.0	63.2	0.1	0.2	26.5	0.5	0.8	64.0	1,754	446	388	72	89	144	75	221
Norman Powell	+277	349	20.2	9.9	2.4	1.4	0.8	0.2	1.1	3.6	7.7	46.6	1.3	3.3	37.9	1.5	1.8	83.0	7,036	3,463	854	477	264	82	387	599
Charles Oakley	+253	208	32.8	7.9	8.0	3.3	1.1	0.5	1.9	3.3	8.0	40.6	0.1	0.5	27.4	1.3	1.5	81.3	6,831	1,644	1,655	685	224	114	389	734
DeMar DeRozan	+225	675	34.1	19.7	4.1	3.1	1.0	0.3	2.0	7.0	15.6	44.8	0.5	1.7	28.8	5.2	6.3	82.7	22,987	13,296	2,739	2,078	655	185	1,323	1,499