The Buffalo Bills lost when scoring 2+ interception touchdowns against the Cowboys on October 8, 2007.
Interpreted as:
2 or more defensive touchdowns in a regular-season game by a team that lost| TEAM | DATE | L | INT TD | TM | OPP | RESULT | TKL | AST | COMB | SCK | SCKY | INT | INT YDS | FF | FR | FR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/8/2007 | 1 | 2 | vs | L 24-25 | 55 | 10 | 65 | 0.0 | 0 | 5 | 67 | 2 | 1 | 0 | ||
| 2 |  | Lions | 10/16/2005 | 1 | 2 | vs | L 20-21 | 49 | 19 | 68 | 2.0 | 20 | 3 | 98 | 3 | 1 | 0 | ||
| 3 |  | Cowboys | 11/4/2001 | 1 | 2 | @ | L 24-27 | 60 | 14 | 74 | 4.0 | 15 | 2 | 100 | 5 | 3 | 0 | ||
| 4 |  | Patriots | 10/17/1999 | 1 | 2 | vs | L 30-31 | 9.0 | 53 | 2 | 84 | 0 | 0 | ||||||
| 5 |  | Cardinals | 11/26/1961 | 1 | 2 | @ | L 27-30 | 0.0 | 0 | 5 | 124 | 2 | 0 |
STLResults may be incomplete. StatMuse has complete team, game-level data for interception touchdowns going back to the 1940 season.
More Bills Stats
Team Leaders 
PASS
556
Allen
RUSH
163
Cook
REC
157
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
