The San Francisco 49ers are 4-3 against the Bills in the regular season and playoffs at home on Sundays all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/21/1980 | 0-1 | vs | L 13-18 | .000 | 2 | 19 | 298 | 267 | ||||
| 2 | | 49ers | 12/17/1989 | 1-0 | vs | W 21-10 | 1.000 | 3 | 18 | 283 | 301 | ||||
| 3 | | 49ers | 9/13/1992 | 0-1 | vs | L 31-34 | .000 | 4 | 26 | 598 | 488 | 61.5 | 100.0 | ||
| 4 | | 49ers | 12/3/1995 | 1-0 | vs | W 27-17 | 1.000 | 3 | 18 | 323 | 275 | 31.3 | 50.0 | ||
| 5 | | 49ers | 12/2/2001 | 1-0 | vs | W 35-0 | 1.000 | 5 | 26 | 409 | 191 | 66.7 | 0.0 | ||
| 6 | | 49ers | 12/26/2004 | 0-1 | vs | L 7-41 | .000 | 1 | 12 | 189 | 441 | 30.0 | 100.0 | ||
| 7 | | 49ers | 10/7/2012 | 1-0 | vs | W 45-3 | 1.000 | 6 | 29 | 621 | 204 | 63.6 | 100.0 | ||
| Average | .571 | 3.4 | 21.1 | 388.7 | 309.6 | ||||||||||
| Total | 4-3 | .571 | 24 | 148 | 2,721 | 2,167 |
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More 49ers Stats
Team Leaders 
PASS
1,748
Purdy
RUSH
389
McCaffrey
REC
425
Kittle
Team Rankings
PPG
28.1
3rd
OPP PPG
19.9
6th
RUSH YDS/G
127.4
8th
PASS YDS/G
249.7
12th
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DAL
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NYG
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NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 2 | 1 | .643 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
1 | 4 | 1 | .250 | |
| NFC North | W | L | T | PCT |
6 | 0 | 0 | 1.000 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| NFC South | W | L | T | PCT |
3 | 3 | 0 | .500 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
| NFC West | W | L | T | PCT |
6 | 1 | 0 | .857 | |
4 | 3 | 0 | .571 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 |
Eagles
Commanders
Bears
Lions
Packers
Panthers
Falcons
Buccaneers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 1 | 0 | .833 | |
4 | 3 | 0 | .571 | |
2 | 5 | 0 | .286 | |
1 | 5 | 0 | .167 | |
| AFC North | W | L | T | PCT |
5 | 2 | 0 | .714 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| AFC South | W | L | T | PCT |
4 | 2 | 0 | .667 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
1 | 6 | 0 | .143 | |
| AFC West | W | L | T | PCT |
5 | 1 | 0 | .833 | |
5 | 2 | 0 | .714 | |
3 | 4 | 0 | .429 | |
0 | 6 | 0 | .000 |
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