The San Francisco 49ers had a point differential of -22 points against the Cardinals on the road between the 2002 and 2015 seasons.
| TEAM | DATE | DIFF | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/21/2002 | 3 | @ | W 17-14 | 2 | 21 | 358 | 184 | 55.0 | 50.0 | ||
| 2 | | 49ers | 10/26/2003 | -3 | @ | L 13-16 | 2 | 15 | 255 | 314 | 50.0 | |||
| 3 | | 49ers | 12/12/2004 | 3 | @ | W 31-28 | 4 | 23 | 352 | 374 | 35.3 | 100.0 | ||
| 4 | | 49ers | 10/2/2005 | -17 | @ | L 14-31 | 2 | 8 | 168 | 463 | 33.3 | 0.0 | ||
| 5 | | 49ers | 9/10/2006 | -7 | @ | L 27-34 | 3 | 19 | 393 | 367 | 11.1 | 100.0 | ||
| 6 | | 49ers | 11/25/2007 | 6 | @ | W 37-31 | 5 | 21 | 374 | 552 | 30.8 | 0.0 | ||
| 7 | | 49ers | 11/10/2008 | -5 | @ | L 24-29 | 3 | 19 | 336 | 374 | 50.0 | |||
| 8 | | 49ers | 9/13/2009 | 4 | @ | W 20-16 | 2 | 13 | 203 | 299 | 38.9 | |||
| 9 | | 49ers | 11/29/2010 | 21 | @ | W 27-6 | 3 | 26 | 386 | 203 | 53.8 | |||
| 10 | | 49ers | 12/11/2011 | -2 | @ | L 19-21 | 1 | 12 | 233 | 325 | 17.6 | 50.0 | ||
| 11 | | 49ers | 10/29/2012 | 21 | @ | W 24-3 | 3 | 15 | 317 | 265 | 50.0 | |||
| 12 | | 49ers | 12/29/2013 | 3 | @ | W 23-20 | 2 | 19 | 375 | 482 | 23.1 | 0.0 | ||
| 13 | | 49ers | 9/21/2014 | -9 | @ | L 14-23 | 2 | 20 | 318 | 338 | 50.0 | 100.0 | ||
| 14 | | 49ers | 9/27/2015 | -40 | @ | L 7-47 | 1 | 10 | 156 | 446 | 33.3 | |||
| Average | -1.6 | 2.5 | 17.2 | 301.7 | 356.1 | 39.0 | 0.1 | |||||||
| Total | -22 | 35 | 241 | 4,224 | 4,986 | 39.0 | 45.5 |
More NFL News
Police seek people responsible for break-in at Eagles' running back Saquon Barkley’s home
Titans' Jeffery Simmons is voted the top interior defensive lineman in the NFL by an AP panel
Joe Thuney of the Bears is voted as the top interior offensive lineman in the NFL by an AP panel
Baltimore's Kyle Hamilton voted top safety in the NFL by AP panel
NFL suspends Arizona Cardinals executive indefinitely for violating league’s gambling policy, AP source says
Titans to honor ALS-diagnosed Chris Johnson by inducting him into Ring of Honor
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |