The San Francisco 49ers have a record of 25-18 against the AFC in the regular-season and playoffs at home since 2006.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/8/2006 | 1-0 | vs | W 34-20 | 1.000 | 4 | 18 | 330 | 370 | 45.5 | 0.0 | ||
| 2 | | 49ers | 10/15/2006 | 0-1 | vs | L 19-48 | .000 | 2 | 15 | 274 | 421 | 36.4 | 0.0 | ||
| 3 | | 49ers | 10/7/2007 | 0-1 | vs | L 7-9 | .000 | 1 | 6 | 163 | 315 | 25.0 | |||
| 4 | | 49ers | 12/15/2007 | 1-0 | vs | W 20-13 | 1.000 | 2 | 22 | 337 | 313 | 60.0 | 0.0 | ||
| 5 | | 49ers | 10/5/2008 | 0-1 | vs | L 21-30 | .000 | 3 | 12 | 199 | 377 | 11.1 | 0.0 | ||
| 6 | | 49ers | 12/7/2008 | 1-0 | vs | W 24-14 | 1.000 | 3 | 25 | 375 | 182 | 53.3 | 100.0 | ||
| 7 | | 49ers | 11/8/2009 | 0-1 | vs | L 27-34 | .000 | 3 | 25 | 358 | 315 | 30.8 | 100.0 | ||
| 8 | | 49ers | 11/29/2009 | 1-0 | vs | W 20-3 | 1.000 | 2 | 15 | 284 | 357 | 50.0 | 100.0 | ||
| 9 | | 49ers | 10/17/2010 | 1-0 | vs | W 17-9 | 1.000 | 2 | 17 | 349 | 179 | 41.2 | |||
| 10 | | 49ers | 10/31/2010 | 1-0 | vs | W 24-16 | 1.000 | 3 | 16 | 339 | 398 | 38.5 | |||
| 11 | | 49ers | 10/30/2011 | 1-0 | vs | W 20-10 | 1.000 | 2 | 19 | 348 | 290 | 40.0 | 0.0 | ||
| 12 | | 49ers | 12/19/2011 | 1-0 | vs | W 20-3 | 1.000 | 2 | 17 | 287 | 389 | 30.8 | |||
| 13 | | 49ers | 10/7/2012 | 1-0 | vs | W 45-3 | 1.000 | 6 | 29 | 621 | 204 | 63.6 | 100.0 | ||
| 14 | | 49ers | 12/9/2012 | 1-0 | vs | W 27-13 | 1.000 | 3 | 20 | 321 | 227 | 20.0 | |||
| 15 | | 49ers | 2/3/2013 | 0-1 | vs | L 31-34 | .000 | 3 | 23 | 468 | 367 | 22.2 | 0.0 | ||
| 16 | | 49ers | 9/22/2013 | 0-1 | vs | L 7-27 | .000 | 1 | 14 | 254 | 336 | 25.0 | 100.0 | ||
| 17 | | 49ers | 10/6/2013 | 1-0 | vs | W 34-3 | 1.000 | 4 | 17 | 284 | 313 | 36.4 | 0.0 | ||
| 18 | | 49ers | 10/5/2014 | 1-0 | vs | W 22-17 | 1.000 | 1 | 22 | 357 | 265 | 37.5 | 100.0 | ||
| 19 | | 49ers | 12/20/2014 | 0-1 | vs | L 35-38 | .000 | 5 | 21 | 447 | 446 | 45.5 | 0.0 | ||
| 20 | | 49ers | 10/18/2015 | 1-0 | vs | W 25-20 | 1.000 | 2 | 15 | 391 | 420 | 38.5 | |||
| 21 | | 49ers | 12/20/2015 | 0-1 | vs | L 14-24 | .000 | 2 | 17 | 318 | 242 | 14.3 | 100.0 | ||
| 22 | | 49ers | 11/20/2016 | 0-1 | vs | L 17-30 | .000 | 2 | 20 | 299 | 444 | 35.7 | |||
| 23 | | 49ers | 12/11/2016 | 0-1 | vs | L 17-23 | .000 | 2 | 17 | 364 | 404 | 16.7 | 0.0 | ||
| 24 | | 49ers | 12/17/2017 | 1-0 | vs | W 25-23 | 1.000 | 1 | 23 | 414 | 328 | 50.0 | |||
| 25 | | 49ers | 12/24/2017 | 1-0 | vs | W 44-33 | 1.000 | 6 | 26 | 369 | 472 | 66.7 | |||
| Average | .581 | 2.6 | 20.1 | 363.1 | 324.9 | 40.8 | 0.0 | ||||||||
| Total | 25-18 | .581 | 113 | 864 | 15,615 | 13,971 | 40.8 | 43.2 | |||||||
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |