The San Francisco 49ers are 3-3-1 against the spread as underdogs against the AFC South on the road since 1970.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/27/2005 | 0-1 |  SF | @ |  TEN | L 22-33 | +8 | -3 (N) | 42.5 | +12.5 (O) | 3 | 15 | 261 | 461 | 20.0 | 100.0 | ||
| 2 | | 49ers | 12/18/2005 | 1-0 | SF | @ |  JAX | L 9-10 | +15.5 | +14.5 (Y) | 37.5 | -18.5 (U) | 0 | 11 | 217 | 336 | 7.7 | 0.0 | ||
| 3 | | 49ers | 10/25/2009 | 0-0-1 | SF | +160 | @ |  HOU | -185 | L 21-24 | +3 | 0 (P) | 44.5 | +0.5 (O) | 3 | 17 | 297 | 336 | 36.4 | 0.0 |
| 4 | | 49ers | 11/1/2009 | 1-0 | SF | +550 | @ |  IND | -800 | L 14-18 | +12.5 | +8.5 (Y) | 44.5 | -12.5 (U) | 2 | 16 | 295 | 410 | 20.0 | |
| 5 | | 49ers | 10/8/2017 | 0-1 | SF | +105 | @ | IND | -125 | L 23-26 | +1.5 | -1.5 (N) | 44 | +5 (O) | 2 | 23 | 402 | 447 | 28.6 | 100.0 |
| 6 | | 49ers | 12/10/2017 | 1-0 | SF | +108 | @ | HOU | -118 | W 26-16 | -1.5 | +8.5 (Y) | 45.5 | -3.5 (U) | 2 | 20 | 416 | 311 | 18.2 | |
| 7 | | 49ers | 10/26/2025 | 0-1 | SF | +135 | @ | HOU | -159 | L 15-26 | +3 | -8 (N) | 42 | -1 (U) | 2 | 12 | 223 | 475 | 33.3 | 0.0 |
| Average | 7.1 | 2.0 | 16.3 | 301.6 | 396.6 | 22.9 | 11.1 | |||||||||||||
| Total | 3-3-1 | 14 | 114 | 2,111 | 2,776 | 22.9 | 55.6 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
20.0
26th
OPP PPG
20.5
8th
RUSH YDS/G
89.4
30th
PASS YDS/G
272.9
2nd
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