The San Francisco 49ers have a record of 1-2 against the spread as underdogs against the AFC South on the road since 2017.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/8/2017 | 0-1 |  SF | +105 | @ |  IND | -125 | L 23-26 | +1.5 | -1.5 (N) | 44 | +5 (O) | 2 | 23 | 402 | 447 | 28.6 | 100.0 |
| 2 | | 49ers | 12/10/2017 | 1-0 | SF | +108 | @ |  HOU | -118 | W 26-16 | -1.5 | +8.5 (Y) | 45.5 | -3.5 (U) | 2 | 20 | 416 | 311 | 18.2 | |
| 3 | | 49ers | 10/26/2025 | 0-1 | SF | +135 | @ | HOU | -159 | L 15-26 | +3 | -8 (N) | 42 | -1 (U) | 2 | 12 | 223 | 475 | 33.3 | 0.0 |
| Average | 11.1 | 2.0 | 18.3 | 347.0 | 411.0 | 26.5 | 33.3 | |||||||||||||
| Total | 1-2 | 6 | 55 | 1,041 | 1,233 | 26.5 | 66.7 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
20.0
26th
OPP PPG
20.5
8th
RUSH YDS/G
89.4
30th
PASS YDS/G
272.9
2nd
Rams
Seahawks
Cardinals
NYG
CAR
CLE
Patriots
Bills
Steelers
Bengals
Jaguars
Broncos
Chargers
Eagles
Cowboys
Packers
Lions
Buccaneers
KC
NYJ
ATL
LV
WAS
BAL
MIA
MIN
CHI
