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The San Francisco 49ers had the highest point differential by a team in 2022, with a 173-point differential.
| TEAM | SEASON | GP | DIFF | W | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 San Francisco 49ers | 2022 | 17 | 173 | 13 | 4 | 0 | 53 | 450 | 26.5 | 277 | 16.3 | 347 | 45.0 | 41.2 |
 Buffalo Bills | 2022 | 16 | 169 | 13 | 3 | 0 | 53 | 455 | 28.4 | 286 | 17.9 | 367 | 50.3 | 53.8 |
 Philadelphia Eagles | 2022 | 17 | 133 | 14 | 3 | 0 | 59 | 477 | 28.1 | 344 | 20.2 | 385 | 45.9 | 68.8 |
 Kansas City Chiefs | 2022 | 17 | 127 | 14 | 3 | 0 | 61 | 496 | 29.2 | 369 | 21.7 | 408 | 48.7 | 75.0 |
 Dallas Cowboys | 2022 | 17 | 125 | 12 | 5 | 0 | 55 | 467 | 27.5 | 342 | 20.1 | 347 | 45.5 | 52.6 |
 Cincinnati Bengals | 2022 | 16 | 96 | 12 | 4 | 0 | 50 | 418 | 26.1 | 322 | 20.1 | 357 | 46.1 | 25.0 |
 Jacksonville Jaguars | 2022 | 17 | 54 | 9 | 8 | 0 | 45 | 404 | 23.8 | 350 | 20.6 | 352 | 41.9 | 51.9 |
 Baltimore Ravens | 2022 | 17 | 35 | 10 | 7 | 0 | 34 | 350 | 20.6 | 315 | 18.5 | 337 | 41.7 | 40.0 |
 Detroit Lions | 2022 | 17 | 26 | 9 | 8 | 0 | 54 | 453 | 26.6 | 427 | 25.1 | 376 | 40.8 | 54.1 |
 New England Patriots | 2022 | 17 | 17 | 8 | 9 | 0 | 39 | 364 | 21.4 | 347 | 20.4 | 288 | 34.9 | 38.5 |
 Los Angeles Chargers | 2022 | 17 | 7 | 10 | 7 | 0 | 42 | 391 | 23.0 | 384 | 22.6 | 352 | 43.6 | 51.7 |
 Seattle Seahawks | 2022 | 17 | 6 | 9 | 8 | 0 | 44 | 407 | 23.9 | 401 | 23.6 | 346 | 37.8 | 57.1 |
 Green Bay Packers | 2022 | 17 | -1 | 8 | 9 | 0 | 42 | 370 | 21.8 | 371 | 21.8 | 334 | 39.5 | 38.7 |
 Miami Dolphins | 2022 | 17 | -2 | 9 | 8 | 0 | 46 | 397 | 23.4 | 399 | 23.5 | 342 | 36.2 | 54.2 |
 Minnesota Vikings | 2022 | 17 | -3 | 13 | 4 | 0 | 50 | 424 | 24.9 | 427 | 25.1 | 382 | 41.2 | 47.4 |
 New York Giants | 2022 | 17 | -6 | 9 | 7 | 1 | 40 | 365 | 21.5 | 371 | 21.8 | 352 | 36.8 | 47.6 |
 New Orleans Saints | 2022 | 17 | -15 | 7 | 10 | 0 | 37 | 330 | 19.4 | 345 | 20.3 | 305 | 40.2 | 36.4 |
 Cleveland Browns | 2022 | 17 | -20 | 7 | 10 | 0 | 42 | 361 | 21.2 | 381 | 22.4 | 350 | 38.1 | 54.8 |
 New York Jets | 2022 | 17 | -20 | 7 | 10 | 0 | 29 | 296 | 17.4 | 316 | 18.6 | 294 | 34.6 | 39.3 |
 Atlanta Falcons | 2022 | 17 | -21 | 7 | 10 | 0 | 38 | 365 | 21.5 | 386 | 22.7 | 330 | 41.8 | 50.0 |
 Washington Commanders | 2022 | 17 | -22 | 8 | 8 | 1 | 36 | 321 | 18.9 | 343 | 20.2 | 339 | 35.2 | 48.0 |
 Las Vegas Raiders | 2022 | 17 | -23 | 6 | 11 | 0 | 43 | 395 | 23.2 | 418 | 24.6 | 343 | 39.9 | 54.2 |
 Carolina Panthers | 2022 | 17 | -27 | 7 | 10 | 0 | 36 | 347 | 20.4 | 374 | 22.0 | 281 | 31.7 | 57.1 |
 Pittsburgh Steelers | 2022 | 17 | -38 | 9 | 8 | 0 | 29 | 308 | 18.1 | 346 | 20.4 | 345 | 44.9 | 73.3 |
 Tampa Bay Buccaneers | 2022 | 17 | -45 | 8 | 9 | 0 | 32 | 313 | 18.4 | 358 | 21.1 | 346 | 37.4 | 55.6 |
 Tennessee Titans | 2022 | 17 | -61 | 7 | 10 | 0 | 34 | 298 | 17.5 | 359 | 21.1 | 277 | 36.5 | 52.9 |
 Denver Broncos | 2022 | 17 | -72 | 5 | 12 | 0 | 29 | 287 | 16.9 | 359 | 21.1 | 300 | 29.1 | 50.0 |
 Los Angeles Rams | 2022 | 17 | -77 | 5 | 12 | 0 | 32 | 307 | 18.1 | 384 | 22.6 | 293 | 39.3 | 78.9 |
 Arizona Cardinals | 2022 | 17 | -109 | 4 | 13 | 0 | 37 | 340 | 20.0 | 449 | 26.4 | 326 | 35.2 | 43.9 |
 Houston Texans | 2022 | 17 | -131 | 3 | 13 | 1 | 29 | 289 | 17.0 | 420 | 24.7 | 277 | 30.3 | 50.0 |
 Chicago Bears | 2022 | 17 | -137 | 3 | 14 | 0 | 37 | 326 | 19.2 | 463 | 27.2 | 278 | 40.9 | 32.0 |
 Indianapolis Colts | 2022 | 17 | -138 | 4 | 12 | 1 | 28 | 289 | 17.0 | 427 | 25.1 | 310 | 32.9 | 46.2 |