The Buffalo Bills had the highest point differential by a team in a Week-5 game in 2022, with a 35-point differential versus the Steelers on October 9, 2022.
| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 35 | 10/9/2022 | vs | W 38-3 | 5 | 21 | 552 | 364 | 55.6 | |||
| 2 |  | Patriots | 29 | 10/9/2022 | vs | W 29-0 | 2 | 22 | 364 | 312 | 33.3 | |||
| 3 |  | Jets | 23 | 10/9/2022 | vs | W 40-17 | 5 | 21 | 322 | 295 | 45.5 | 0.0 | ||
| 4 |  | 49ers | 22 | 10/9/2022 | @ | W 37-15 | 5 | 22 | 397 | 308 | 58.3 | |||
| 5 |  | Cowboys | 12 | 10/9/2022 | @ | W 22-10 | 2 | 10 | 239 | 323 | 33.3 | |||
| 6 |  | Vikings | 7 | 10/9/2022 | vs | W 29-22 | 4 | 29 | 429 | 271 | 80.0 | |||
| 7 |  | Texans | 7 | 10/9/2022 | @ | W 13-6 | 1 | 15 | 248 | 422 | 38.5 | |||
| 8 |  | Saints | 7 | 10/9/2022 | vs | W 39-32 | 5 | 26 | 438 | 396 | 57.1 | |||
| 9 |  | Buccaneers | 6 | 10/9/2022 | vs | W 21-15 | 2 | 26 | 420 | 261 | 56.3 | 0.0 | ||
| 10 |  | Giants | 5 | 10/9/2022 | @ | W 27-22 | 3 | 24 | 338 | 301 | 54.5 | 0.0 | ||
| 11 |  | Titans | 4 | 10/9/2022 | @ | W 21-17 | 3 | 15 | 241 | 385 | 28.6 | 100.0 | ||
| 12 |  | Eagles | 3 | 10/9/2022 | @ | W 20-17 | 2 | 24 | 357 | 363 | 46.2 | 100.0 | ||
| 13 |  | Colts | 3 | 10/6/2022 | @ | W 12-9 | 0 | 19 | 306 | 375 | 25.0 | |||
| 14 |  | Chargers | 2 | 10/9/2022 | @ | W 30-28 | 3 | 26 | 465 | 443 | 30.0 | 0.0 | ||
| 15 |  | Ravens | 2 | 10/9/2022 | vs | W 19-17 | 1 | 22 | 325 | 291 | 45.5 | 0.0 | ||
| 16 |  | Chiefs | 1 | 10/10/2022 | vs | W 30-29 | 4 | 29 | 368 | 378 | 58.3 | |||
| 17 |  | Raiders | -1 | 10/10/2022 | @ | L 29-30 | 3 | 18 | 378 | 368 | 41.7 | 50.0 | ||
| 18 |  | Browns | -2 | 10/9/2022 | vs | L 28-30 | 4 | 27 | 443 | 465 | 40.0 | 0.0 | ||
| 19 |  | Bengals | -2 | 10/9/2022 | @ | L 17-19 | 2 | 20 | 291 | 325 | 40.0 | 0.0 | ||
| 20 |  | Cardinals | -3 | 10/9/2022 | vs | L 17-20 | 2 | 23 | 363 | 357 | 57.1 | 100.0 | ||
| 21 |  | Broncos | -3 | 10/6/2022 | vs | L 9-12 | 0 | 18 | 375 | 306 | 13.3 | 50.0 | ||
| 22 |  | Commanders | -4 | 10/9/2022 | vs | L 17-21 | 2 | 17 | 385 | 241 | 9.1 | 50.0 | ||
| 23 |  | Packers | -5 | 10/9/2022 | vs | L 22-27 | 2 | 22 | 301 | 338 | 40.0 | 0.0 | ||
| 24 |  | Falcons | -6 | 10/9/2022 | @ | L 15-21 | 2 | 19 | 261 | 420 | 42.9 | 100.0 | ||
| 25 |  | Bears | -7 | 10/9/2022 | @ | L 22-29 | 2 | 14 | 271 | 429 | 40.0 | 100.0 | ||
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |