The Buffalo Bills are 15-10 in the regular season and playoffs against the AFC South at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 11/16/2003 | 0-1 | vs | L 10-12 | .000 | 0 | 17 | 335 | 245 | 23.1 | |||
| 2 | | Bills | 11/23/2003 | 0-1 | vs | L 14-17 | .000 | 2 | 16 | 228 | 326 | 23.1 | 100.0 | ||
| 3 | | Bills | 9/12/2004 | 0-1 | vs | L 10-13 | .000 | 1 | 16 | 242 | 225 | 50.0 | |||
| 4 | | Bills | 9/11/2005 | 1-0 | vs | W 22-7 | 1.000 | 1 | 20 | 316 | 120 | 21.4 | 100.0 | ||
| 5 | | Bills | 11/26/2006 | 1-0 | vs | W 27-24 | 1.000 | 3 | 13 | 241 | 323 | 30.0 | |||
| 6 | | Bills | 12/24/2006 | 0-1 | vs | L 29-30 | .000 | 2 | 22 | 368 | 396 | 20.0 | 50.0 | ||
| 7 | | Bills | 11/1/2009 | 0-1 | vs | L 10-31 | .000 | 1 | 9 | 204 | 439 | 20.0 | 0.0 | ||
| 8 | | Bills | 1/3/2010 | 1-0 | vs | W 30-7 | 1.000 | 3 | 19 | 403 | 157 | 35.7 | |||
| 9 | | Bills | 10/10/2010 | 0-1 | vs | L 26-36 | .000 | 3 | 17 | 306 | 381 | 27.3 | 0.0 | ||
| 10 | | Bills | 12/4/2011 | 0-1 | vs | L 17-23 | .000 | 2 | 18 | 386 | 317 | 43.8 | 50.0 | ||
| 11 | | Bills | 10/21/2012 | 0-1 | vs | L 34-35 | .000 | 4 | 22 | 382 | 390 | 58.3 | 0.0 | ||
| 12 | | Bills | 12/2/2012 | 1-0 | vs | W 34-18 | 1.000 | 4 | 20 | 344 | 236 | 41.7 | 0.0 | ||
| 13 | | Bills | 9/13/2015 | 1-0 | vs | W 27-14 | 1.000 | 3 | 15 | 342 | 304 | 38.5 | |||
| 14 | | Bills | 12/6/2015 | 1-0 | vs | W 30-21 | 1.000 | 4 | 15 | 390 | 401 | 50.0 | |||
| 15 | | Bills | 11/27/2016 | 1-0 | vs | W 28-21 | 1.000 | 4 | 15 | 304 | 301 | 41.7 | 100.0 | ||
| 16 | | Bills | 12/10/2017 | 1-0 | vs | W 13-7 | 1.000 | 2 | 14 | 319 | 227 | 55.6 | 0.0 | ||
| 17 | | Bills | 10/7/2018 | 1-0 | vs | W 13-12 | 1.000 | 1 | 18 | 223 | 221 | 30.8 | 66.7 | ||
| 18 | | Bills | 11/25/2018 | 1-0 | vs | W 24-21 | 1.000 | 3 | 18 | 327 | 333 | 20.0 | |||
| 19 | | Bills | 1/9/2021 | 1-0 | vs | W 27-24 | 1.000 | 3 | 22 | 397 | 472 | 22.2 | |||
| 20 | | Bills | 10/3/2021 | 1-0 | vs | W 40-0 | 1.000 | 4 | 26 | 450 | 109 | 41.7 | 50.0 | ||
| 21 | | Bills | 11/21/2021 | 0-1 | vs | L 15-41 | .000 | 2 | 19 | 311 | 370 | 50.0 | |||
| 22 | | Bills | 9/19/2022 | 1-0 | vs | W 41-7 | 1.000 | 5 | 23 | 414 | 187 | 38.5 | 66.7 | ||
| 23 | | Bills | 10/8/2023 | 0-1 | vs | L 20-25 | .000 | 3 | 18 | 388 | 474 | 41.7 | |||
| 24 | | Bills | 9/23/2024 | 1-0 | vs | W 47-10 | 1.000 | 6 | 25 | 388 | 239 | 54.5 | 100.0 | ||
| 25 | | Bills | 10/20/2024 | 1-0 | vs | W 34-10 | 1.000 | 4 | 18 | 389 | 289 | 30.0 | |||
| Average | .600 | 2.8 | 18.2 | 335.9 | 299.3 | 37.3 | 0.0 | ||||||||
| Total | 15-10 | .600 | 70 | 455 | 8,397 | 7,482 | 37.3 | 53.6 |
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More Bills Stats
Team Leaders 
PASS
1,793
Allen
RUSH
707
Cook
REC
401
Kincaid
Team Rankings
PPG
33.3
1st
OPP PPG
25.9
23rd
RUSH YDS/G
148.4
3rd
PASS YDS/G
256.1
9th
Patriots
Jets
Dolphins
MIN
KC
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
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NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 2 | 1 | .643 | |
3 | 5 | 0 | .375 | |
2 | 4 | 1 | .357 | |
2 | 6 | 0 | .250 | |
| NFC North | W | L | T | PCT |
6 | 1 | 0 | .857 | |
6 | 2 | 0 | .750 | |
5 | 2 | 0 | .714 | |
5 | 3 | 0 | .625 | |
| NFC South | W | L | T | PCT |
3 | 4 | 0 | .429 | |
3 | 5 | 0 | .375 | |
3 | 5 | 0 | .375 | |
2 | 5 | 0 | .286 | |
| NFC West | W | L | T | PCT |
6 | 1 | 0 | .857 | |
4 | 4 | 0 | .500 | |
4 | 4 | 0 | .500 | |
3 | 5 | 0 | .375 |
Giants
Cowboys
Commanders
Eagles
Bears
Lions
Packers
Panthers
Buccaneers
Falcons
Saints
49ers
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
6 | 1 | 0 | .857 | |
5 | 3 | 0 | .625 | |
2 | 6 | 0 | .250 | |
1 | 6 | 0 | .143 | |
| AFC North | W | L | T | PCT |
6 | 2 | 0 | .750 | |
5 | 2 | 0 | .714 | |
5 | 3 | 0 | .625 | |
4 | 5 | 0 | .444 | |
| AFC South | W | L | T | PCT |
6 | 2 | 0 | .750 | |
2 | 5 | 0 | .286 | |
2 | 6 | 0 | .250 | |
1 | 7 | 0 | .125 | |
| AFC West | W | L | T | PCT |
6 | 2 | 0 | .750 | |
5 | 2 | 0 | .714 | |
4 | 4 | 0 | .500 | |
0 | 7 | 0 | .000 |
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Ravens
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Raiders
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