The Buffalo Bills have an 11-13-1 record against the spread as favorites in their last 25 games against the AFC South.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/11/2005 | 1-0 | vs | W 22-7 | -5.5 | +9.5 (Y) | 38 | -9 (U) | 1 | 20 | 316 | 120 | 21.4 | 100.0 | ||||
| 2 | | Bills | 12/24/2006 | 0-1 | -220 | vs | +180 | L 29-30 | -5 | -6 (N) | 37 | +22 (O) | 2 | 22 | 368 | 396 | 20.0 | 50.0 | ||
| 3 | | Bills | 1/3/2010 | 1-0 | -380 | vs | +310 | W 30-7 | -8.5 | +14.5 (Y) | 32.5 | +4.5 (O) | 3 | 19 | 403 | 157 | 35.7 | |||
| 4 | | Bills | 10/10/2010 | 0-1 | -140 | vs | +120 | L 26-36 | -1 | -11 (N) | 41 | +21 (O) | 3 | 17 | 306 | 381 | 27.3 | 0.0 | ||
| 5 | | Bills | 12/4/2011 | 0-1 | -120 | vs | +100 | L 17-23 | -1 | -7 (N) | 42.5 | -2.5 (U) | 2 | 18 | 386 | 317 | 43.8 | 50.0 | ||
| 6 | | Bills | 10/21/2012 | 0-1 | -215 | vs | +185 | L 34-35 | -4 | -5 (N) | 46.5 | +22.5 (O) | 4 | 22 | 382 | 390 | 58.3 | 0.0 | ||
| 7 | | Bills | 12/2/2012 | 1-0 | -265 | vs | +225 | W 34-18 | -6 | +10 (Y) | 41 | +11 (O) | 4 | 20 | 344 | 236 | 41.7 | 0.0 | ||
| 8 | | Bills | 12/15/2013 | 1-0 | -205 | @ | +175 | W 27-20 | -4 | +3 (Y) | 43.5 | +3.5 (O) | 3 | 25 | 366 | 354 | 38.5 | |||
| 9 | | Bills | 10/11/2015 | 0-0-1 | -115 | @ | -105 | W 14-13 | -1 | 0 (P) | 43 | -16 (U) | 2 | 13 | 209 | 276 | 33.3 | |||
| 10 | | Bills | 10/25/2015 | 0-1 | -200 | @ | +160 | L 31-34 | -4 | -7 (N) | 42 | +23 (O) | 3 | 26 | 375 | 295 | 25.0 | 0.0 | ||
| 11 | | Bills | 12/6/2015 | 1-0 | -155 | vs | +135 | W 30-21 | -3 | +6 (Y) | 42 | +9 (O) | 4 | 15 | 390 | 401 | 50.0 | |||
| 12 | | Bills | 11/27/2016 | 0-1 | -400 | vs | +330 | W 28-21 | -8.5 | -1.5 (N) | 44 | +5 (O) | 4 | 15 | 304 | 301 | 41.7 | 100.0 | ||
| 13 | | Bills | 12/10/2017 | 1-0 | -180 | vs | +160 | W 13-7 | -3 | +3 (Y) | 36.5 | -16.5 (U) | 2 | 14 | 319 | 227 | 55.6 | 0.0 | ||
| 14 | | Bills | 10/13/2020 | 0-1 | -166 | @ | +141 | L 16-42 | -3 | -29 (N) | 52 | +6 (O) | 2 | 23 | 370 | 334 | 76.5 | |||
| 15 | | Bills | 1/9/2021 | 0-1 | -347 | vs | +278 | W 27-24 | -7 | -4 (N) | 51 | 0 (P) | 3 | 22 | 397 | 472 | 22.2 | |||
| 16 | | Bills | 10/3/2021 | 1-0 | -1784 | vs | +957 | W 40-0 | -19 | +21 (Y) | 47.5 | -7.5 (U) | 4 | 26 | 450 | 109 | 41.7 | 50.0 | ||
| 17 | | Bills | 10/18/2021 | 0-1 | -270 | @ | +218 | L 31-34 | -6 | -9 (N) | 53.5 | +11.5 (O) | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 18 | | Bills | 11/7/2021 | 0-1 | -1144 | @ | +704 | L 6-9 | -14.5 | -17.5 (N) | 48.5 | -33.5 (U) | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 19 | | Bills | 11/21/2021 | 0-1 | -310 | vs | +244 | L 15-41 | -7 | -33 (N) | 49.5 | +6.5 (O) | 2 | 19 | 311 | 370 | 50.0 | |||
| 20 | | Bills | 9/19/2022 | 1-0 | -453 | vs | +349 | W 41-7 | -10 | +24 (Y) | 47.5 | +0.5 (O) | 5 | 23 | 414 | 187 | 38.5 | 66.7 | ||
| 21 | | Bills | 10/8/2023 | 0-1 | -242 | vs | +198 | L 20-25 | -5 | -10 (N) | 48.5 | -3.5 (U) | 3 | 18 | 388 | 474 | 41.7 | |||
| 22 | | Bills | 9/23/2024 | 1-0 | -227 | vs | +186 | W 47-10 | -4.5 | +32.5 (Y) | 46.5 | +10.5 (O) | 6 | 25 | 388 | 239 | 54.5 | 100.0 | ||
| 23 | | Bills | 10/20/2024 | 1-0 | -521 | vs | +390 | W 34-10 | -9 | +15 (Y) | 41 | +3 (O) | 4 | 18 | 389 | 289 | 30.0 | |||
| 24 | | Bills | 11/10/2024 | 1-0 | -227 | @ | +187 | W 30-20 | -4.5 | +5.5 (Y) | 46.5 | +3.5 (O) | 3 | 21 | 415 | 361 | 50.0 | 66.7 | ||
| 25 | | Bills | 11/20/2025 | 0-1 | -235 | @ | +193 | L 19-23 | -4.5 | -8.5 (N) | 44 | -2 (U) | 2 | 14 | 326 | 261 | 31.3 | 60.0 | ||
| Average | 1.8 | 3.0 | 20.0 | 361.4 | 301.1 | 42.0 | 0.0 | |||||||||||||
| Total | 11-13-1 | 74 | 500 | 9,034 | 7,527 | 42.0 | 46.9 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More NFL News
Packers defensive lineman Devonte Wyatt agrees to 3-year, $57 million extension, AP source says
Police seek people responsible for break-in at Eagles' running back Saquon Barkley’s home
Titans' Jeffery Simmons is voted the top interior defensive lineman in the NFL by an AP panel
Joe Thuney of the Bears is voted as the top interior offensive lineman in the NFL by an AP panel
Baltimore's Kyle Hamilton voted top safety in the NFL by AP panel
NFL suspends Arizona Cardinals executive indefinitely for violating league’s gambling policy, AP source says
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |