The Buffalo Bills are 19-13 against the spread in the regular season against the AFC West since 2010.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/31/2010 | 1-0 | +265 | @ | -325 | L 10-13 | +7 | +4 (Y) | 45.5 | -22.5 (U) | 1 | 23 | 328 | 414 | 47.8 | 50.0 | ||
| 2 | | Bills | 9/11/2011 | 1-0 | +180 | @ | -210 | W 41-7 | +4 | +38 (Y) | 40 | +8 (O) | 5 | 23 | 364 | 213 | 50.0 | |||
| 3 | | Bills | 9/18/2011 | 0-1 | -200 | vs | +175 | W 38-35 | -4 | -1 (N) | 41 | +32 (O) | 5 | 34 | 481 | 454 | 36.4 | 100.0 | ||
| 4 | | Bills | 12/11/2011 | 0-1 | +280 | @ | -340 | L 10-37 | +7 | -20 (N) | 48.5 | -1.5 (U) | 1 | 17 | 281 | 366 | 36.4 | 0.0 | ||
| 5 | | Bills | 12/24/2011 | 1-0 | +130 | vs | -150 | W 40-14 | +3 | +29 (Y) | 42.5 | +11.5 (O) | 4 | 14 | 351 | 285 | 16.7 | |||
| 6 | | Bills | 9/16/2012 | 1-0 | -165 | vs | +145 | W 35-17 | -3 | +15 (Y) | 45 | +7 (O) | 5 | 15 | 379 | 422 | 41.7 | |||
| 7 | | Bills | 11/3/2013 | 0-1 | +195 | vs | -235 | L 13-23 | +4.5 | -5.5 (N) | 40.5 | -4.5 (U) | 1 | 25 | 470 | 210 | 30.8 | 0.0 | ||
| 8 | | Bills | 9/21/2014 | 0-1 | -140 | vs | +120 | L 10-22 | -2.5 | -14.5 (N) | 45.5 | -13.5 (U) | 1 | 18 | 292 | 333 | 42.9 | 0.0 | ||
| 9 | | Bills | 11/9/2014 | 0-1 | -125 | vs | +105 | L 13-17 | -2 | -6 (N) | 42 | -12 (U) | 1 | 21 | 364 | 278 | 43.8 | 0.0 | ||
| 10 | | Bills | 12/7/2014 | 1-0 | +350 | @ | -425 | L 17-24 | +9 | +2 (Y) | 47 | -6 (U) | 2 | 24 | 415 | 306 | 56.3 | 66.7 | ||
| 11 | | Bills | 12/21/2014 | 0-1 | -280 | @ | +240 | L 24-26 | -7 | -9 (N) | 42 | +8 (O) | 3 | 15 | 321 | 347 | 26.7 | |||
| 12 | | Bills | 11/29/2015 | 0-1 | +185 | @ | -215 | L 22-30 | +4 | -4 (N) | 41 | +11 (O) | 3 | 25 | 415 | 413 | 41.7 | 0.0 | ||
| 13 | | Bills | 12/4/2016 | 0-1 | +145 | @ | -165 | L 24-38 | +3 | -11 (N) | 48.5 | +13.5 (O) | 3 | 24 | 382 | 399 | 60.0 | |||
| 14 | | Bills | 9/24/2017 | 1-0 | +160 | vs | -170 | W 26-16 | +3.5 | +13.5 (Y) | 40 | +2 (O) | 2 | 16 | 272 | 366 | 37.5 | |||
| 15 | | Bills | 10/29/2017 | 1-0 | -122 | vs | +112 | W 34-14 | -2 | +18 (Y) | 47.5 | +0.5 (O) | 4 | 17 | 331 | 367 | 40.0 | 100.0 | ||
| 16 | | Bills | 11/19/2017 | 0-1 | +270 | @ | -300 | L 24-54 | +7 | -23 (N) | 41.5 | +36.5 (O) | 3 | 18 | 393 | 429 | 42.9 | 50.0 | ||
| 17 | | Bills | 11/26/2017 | 1-0 | +320 | @ | -355 | W 16-10 | +8 | +14 (Y) | 47 | -21 (U) | 1 | 17 | 268 | 236 | 35.3 | |||
| 18 | | Bills | 9/16/2018 | 0-1 | +270 | vs | -307 | L 20-31 | +7.5 | -3.5 (N) | 41.5 | +9.5 (O) | 2 | 17 | 293 | 349 | 35.7 | |||
| 19 | | Bills | 11/24/2019 | 1-0 | -205 | vs | +169 | W 20-3 | -3.5 | +13.5 (Y) | 37 | -14 (U) | 2 | 22 | 424 | 134 | 50.0 | |||
| 20 | | Bills | 10/4/2020 | 1-0 | -178 | @ | +148 | W 30-23 | -3.5 | +3.5 (Y) | 52.5 | +0.5 (O) | 4 | 21 | 337 | 383 | 53.8 | 100.0 | ||
| 21 | | Bills | 10/19/2020 | 0-1 | +204 | vs | -246 | L 17-26 | +5.5 | -3.5 (N) | 54.5 | -11.5 (U) | 2 | 20 | 206 | 466 | 44.4 | |||
| 22 | | Bills | 11/29/2020 | 1-0 | -217 | vs | +180 | W 27-17 | -4 | +6 (Y) | 51 | -7 (U) | 3 | 23 | 332 | 367 | 44.4 | |||
| 23 | | Bills | 12/19/2020 | 1-0 | -249 | @ | +209 | W 48-19 | -6 | +23 (Y) | 48.5 | +18.5 (O) | 6 | 29 | 534 | 255 | 69.2 | 0.0 | ||
| 24 | | Bills | 10/10/2021 | 1-0 | +124 | @ | -146 | W 38-20 | +3 | +21 (Y) | 56.5 | +1.5 (O) | 5 | 20 | 436 | 392 | 45.5 | |||
| 25 | | Bills | 10/16/2022 | 1-0 | -148 | @ | +124 | W 24-20 | -2.5 | +1.5 (Y) | 54 | -10 (U) | 3 | 26 | 443 | 387 | 36.4 | 33.3 | ||
| Average | 1.9 | 3.0 | 21.2 | 366.0 | 332.6 | 44.5 | 0.0 | |||||||||||||
| Total | 19-13 | 96 | 677 | 11,713 | 10,642 | 44.5 | 47.1 | |||||||||||||
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More Bills Stats
Team Leaders 
PASS
1,039
Allen
RUSH
421
Cook
REC
270
Kincaid
Team Rankings
PPG
31.8
1st
OPP PPG
26.8
25th
RUSH YDS/G
139.0
6th
PASS YDS/G
259.8
10th
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 |
Giants
Eagles
Cowboys
Commanders
Packers
Bears
Lions
Panthers
Falcons
Buccaneers
Saints
49ers
Seahawks
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 |
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