The Buffalo Bills have a record of 46-45-2 against the spread as favorites in the regular season against the AFC since 2014.
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| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/14/2014 | 1-0 | -120 | vs | +100 | W 29-10 | -1 | +18 (Y) | 43 | -4 (U) | 2 | 13 | 315 | 290 | 33.3 | |||
| 2 | | Bills | 9/21/2014 | 0-1 | -140 | vs | +120 | L 10-22 | -2.5 | -14.5 (N) | 45.5 | -13.5 (U) | 1 | 18 | 292 | 333 | 42.9 | 0.0 | ||
| 3 | | Bills | 11/9/2014 | 0-1 | -125 | vs | +105 | L 13-17 | -2 | -6 (N) | 42 | -12 (U) | 1 | 21 | 364 | 278 | 43.8 | 0.0 | ||
| 4 | | Bills | 11/24/2014 | 1-0 | -145 | vs | +125 | W 38-3 | -2 | +33 (Y) | 42 | -1 (U) | 5 | 21 | 336 | 218 | 53.8 | 0.0 | ||
| 5 | | Bills | 11/30/2014 | 1-0 | -170 | vs | +150 | W 26-10 | -3 | +13 (Y) | 42 | -6 (U) | 2 | 15 | 287 | 315 | 13.3 | 100.0 | ||
| 6 | | Bills | 12/21/2014 | 0-1 | -280 | @ | +240 | L 24-26 | -7 | -9 (N) | 42 | +8 (O) | 3 | 15 | 321 | 347 | 26.7 | |||
| 7 | | Bills | 9/20/2015 | 0-1 | -119 | vs | -101 | L 32-40 | -2 | -10 (N) | 45 | +27 (O) | 5 | 23 | 349 | 507 | 30.8 | 100.0 | ||
| 8 | | Bills | 10/11/2015 | 0-0-1 | -115 | @ | -105 | W 14-13 | -1 | 0 (P) | 43 | -16 (U) | 2 | 13 | 209 | 276 | 33.3 | |||
| 9 | | Bills | 10/25/2015 | 0-1 | -200 | @ | +160 | L 31-34 | -4 | -7 (N) | 42 | +23 (O) | 3 | 26 | 375 | 295 | 25.0 | 0.0 | ||
| 10 | | Bills | 11/8/2015 | 1-0 | -200 | vs | +167 | W 33-17 | -4 | +12 (Y) | 44 | +6 (O) | 4 | 18 | 420 | 397 | 61.5 | |||
| 11 | | Bills | 12/6/2015 | 1-0 | -155 | vs | +135 | W 30-21 | -3 | +6 (Y) | 42 | +9 (O) | 4 | 15 | 390 | 401 | 50.0 | |||
| 12 | | Bills | 9/15/2016 | 0-1 | -115 | vs | -105 | L 31-37 | -1 | -7 (N) | 40.5 | +27.5 (O) | 4 | 16 | 393 | 493 | 30.0 | 50.0 | ||
| 13 | | Bills | 10/23/2016 | 0-1 | -140 | @ | +120 | L 25-28 | -2.5 | -5.5 (N) | 46 | +7 (O) | 3 | 16 | 267 | 454 | 23.1 | |||
| 14 | | Bills | 11/27/2016 | 0-1 | -400 | vs | +330 | W 28-21 | -8.5 | -1.5 (N) | 44 | +5 (O) | 4 | 15 | 304 | 301 | 41.7 | 100.0 | ||
| 15 | | Bills | 12/18/2016 | 1-0 | -500 | vs | +350 | W 33-13 | -10.5 | +9.5 (Y) | 43 | +3 (O) | 4 | 29 | 451 | 269 | 44.4 | 0.0 | ||
| 16 | | Bills | 12/24/2016 | 0-1 | -220 | vs | +185 | L 31-34 | -4.5 | -7.5 (N) | 44 | +21 (O) | 4 | 30 | 589 | 494 | 44.4 | 50.0 | ||
| 17 | | Bills | 1/1/2017 | 0-1 | -222 | @ | +180 | L 10-30 | -4.5 | -24.5 (N) | 43 | -3 (U) | 1 | 14 | 230 | 329 | 37.5 | 0.0 | ||
| 18 | | Bills | 9/10/2017 | 1-0 | -360 | vs | +325 | W 21-12 | -7.5 | +1.5 (Y) | 42.5 | -9.5 (U) | 3 | 23 | 408 | 214 | 47.1 | |||
| 19 | | Bills | 10/29/2017 | 1-0 | -122 | vs | +112 | W 34-14 | -2 | +18 (Y) | 47.5 | +0.5 (O) | 4 | 17 | 331 | 367 | 40.0 | 100.0 | ||
| 20 | | Bills | 11/2/2017 | 0-1 | -170 | @ | +160 | L 21-34 | -3 | -16 (N) | 42 | +13 (O) | 3 | 21 | 307 | 331 | 37.5 | 0.0 | ||
| 21 | | Bills | 12/10/2017 | 1-0 | -180 | vs | +160 | W 13-7 | -3 | +3 (Y) | 36.5 | -16.5 (U) | 2 | 14 | 319 | 227 | 55.6 | 0.0 | ||
| 22 | | Bills | 12/17/2017 | 1-0 | -185 | vs | +170 | W 24-16 | -3.5 | +4.5 (Y) | 39.5 | +0.5 (O) | 3 | 21 | 328 | 349 | 46.7 | 0.0 | ||
| 23 | | Bills | 12/31/2017 | 1-0 | -135 | @ | +125 | W 22-16 | -2.5 | +3.5 (Y) | 41.5 | -3.5 (U) | 2 | 23 | 312 | 356 | 41.7 | |||
| 24 | | Bills | 12/9/2018 | 0-1 | -205 | vs | +188 | L 23-27 | -4.5 | -8.5 (N) | 37 | +13 (O) | 2 | 24 | 368 | 248 | 50.0 | |||
| 25 | | Bills | 12/30/2018 | 1-0 | -240 | vs | +220 | W 42-17 | -5.5 | +19.5 (Y) | 39.5 | +19.5 (O) | 6 | 23 | 381 | 225 | 45.5 | 50.0 | ||
| Average | 0.5 | 3.2 | 21.6 | 368.5 | 306.1 | 44.7 | 0.0 | |||||||||||||
| Total | 46-45-2 | 297 | 2,007 | 34,275 | 28,470 | 44.7 | 53.8 | |||||||||||||
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More Bills Stats
Team Leaders 
PASS
1,504
Allen
RUSH
627
Cook
REC
315
Kincaid
Team Rankings
PPG
32.8
1st
OPP PPG
28.5
30th
RUSH YDS/G
148.8
2nd
PASS YDS/G
250.7
11th
Jets
BAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 2 | 1 | .643 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
1 | 4 | 1 | .250 | |
| NFC North | W | L | T | PCT |
6 | 0 | 0 | 1.000 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| NFC South | W | L | T | PCT |
3 | 3 | 0 | .500 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
| NFC West | W | L | T | PCT |
6 | 1 | 0 | .857 | |
4 | 3 | 0 | .571 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 |
Giants
Cowboys
Eagles
Commanders
Bears
Lions
Packers
Panthers
Falcons
Buccaneers
Saints
49ers
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 1 | 0 | .833 | |
4 | 3 | 0 | .571 | |
2 | 5 | 0 | .286 | |
1 | 5 | 0 | .167 | |
| AFC North | W | L | T | PCT |
5 | 2 | 0 | .714 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| AFC South | W | L | T | PCT |
4 | 2 | 0 | .667 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
1 | 6 | 0 | .143 | |
| AFC West | W | L | T | PCT |
5 | 1 | 0 | .833 | |
5 | 2 | 0 | .714 | |
3 | 4 | 0 | .429 | |
0 | 6 | 0 | .000 |
Steelers
Bengals
Broncos