The Buffalo Bills were 42-31-8 against the spread against the NFC between the 2002 and 2021 seasons.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/15/2002 | 1-0 | @ | W 45-39 | +3.5 | +9.5 (Y) | 49 | +35 (O) | 5 | 26 | 468 | 449 | 33.3 | |||||
| 2 | | Bills | 9/29/2002 | 1-0 | vs | W 33-27 | -3 | +3 (Y) | 46.5 | +13.5 (O) | 4 | 26 | 410 | 240 | 45.5 | |||||
| 3 | | Bills | 10/27/2002 | 0-0-1 | vs | W 24-17 | -7 | 0 (P) | 49.5 | -8.5 (U) | 3 | 23 | 343 | 282 | 42.9 | 100.0 | ||||
| 4 | | Bills | 12/22/2002 | 0-1 | @ | L 0-10 | +6.5 | -3.5 (N) | 43 | -33 (U) | 0 | 17 | 185 | 223 | 25.0 | |||||
| 5 | | Bills | 9/28/2003 | 0-1 | vs | L 13-23 | -3 | -13 (N) | 39.5 | -3.5 (U) | 2 | 15 | 308 | 335 | 40.0 | 66.7 | ||||
| 6 | | Bills | 10/19/2003 | 1-0 | vs | W 24-7 | -2.5 | +14.5 (Y) | 39.5 | -8.5 (U) | 3 | 25 | 432 | 169 | 30.0 | |||||
| 7 | | Bills | 11/9/2003 | 0-0-1 | @ | L 6-10 | +4 | 0 (P) | 37 | -21 (U) | 0 | 15 | 185 | 236 | 18.8 | |||||
| 8 | | Bills | 11/30/2003 | 1-0 | @ | W 24-7 | +3.5 | +20.5 (Y) | 35 | -4 (U) | 3 | 23 | 403 | 222 | 35.7 | 100.0 | ||||
| 9 | | Bills | 10/31/2004 | 1-0 | vs | W 38-14 | -3.5 | +20.5 (Y) | 33.5 | +18.5 (O) | 5 | 11 | 209 | 213 | 37.5 | 100.0 | ||||
| 10 | | Bills | 11/21/2004 | 1-0 | vs | W 37-17 | +1 | +21 (Y) | 40 | +14 (O) | 4 | 16 | 294 | 270 | 18.2 | |||||
| 11 | | Bills | 11/28/2004 | 1-0 | @ | W 38-9 | +5.5 | +34.5 (Y) | 38 | +9 (O) | 5 | 25 | 434 | 230 | 60.0 | 50.0 | ||||
| 12 | | Bills | 12/26/2004 | 1-0 | @ | W 41-7 | -11.5 | +22.5 (Y) | 44 | +4 (O) | 5 | 27 | 441 | 189 | 64.3 | 0.0 | ||||
| 13 | | Bills | 9/18/2005 | 0-1 | @ | L 3-19 | +2.5 | -13.5 (N) | 34.5 | -12.5 (U) | 0 | 8 | 147 | 318 | 28.6 | 0.0 | ||||
| 14 | | Bills | 9/25/2005 | 0-1 | vs | L 16-24 | -2.5 | -10.5 (N) | 36 | +4 (O) | 1 | 18 | 208 | 403 | 42.9 | 50.0 | ||||
| 15 | | Bills | 10/2/2005 | 0-1 | @ | L 7-19 | +1 | -11 (N) | 39.5 | -13.5 (U) | 1 | 13 | 208 | 333 | 36.4 | 0.0 | ||||
| 16 | | Bills | 11/27/2005 | 0-0-1 | vs | L 9-13 | +4 | 0 (P) | 36.5 | -14.5 (U) | 0 | 14 | 216 | 295 | 38.5 | 100.0 | ||||
| 17 | | Bills | 10/1/2006 | 1-0 | -130 | vs | +110 | W 17-12 | -1.5 | +3.5 (Y) | 34 | -5 (U) | 2 | 20 | 298 | 330 | 35.7 | |||
| 18 | | Bills | 10/8/2006 | 0-1 | +450 | @ | -600 | L 7-40 | +9 | -24 (N) | 34 | +13 (O) | 1 | 10 | 145 | 351 | 18.2 | 0.0 | ||
| 19 | | Bills | 10/15/2006 | 0-1 | -125 | @ | +105 | L 17-20 | -1 | -4 (N) | 40.5 | -3.5 (U) | 2 | 16 | 242 | 397 | 27.3 | |||
| 20 | | Bills | 11/5/2006 | 1-0 | -180 | vs | +160 | W 24-10 | -3 | +11 (Y) | 41.5 | -7.5 (U) | 3 | 11 | 184 | 427 | 18.2 | |||
| 21 | | Bills | 10/8/2007 | 1-0 | +500 | vs | -700 | L 24-25 | +10 | +9 (Y) | 45 | +4 (O) | 3 | 14 | 229 | 385 | 23.1 | 50.0 | ||
| 22 | | Bills | 12/2/2007 | 1-0 | +245 | @ | -315 | W 17-16 | +6 | +7 (Y) | 37 | -4 (U) | 0 | 15 | 357 | 281 | 38.5 | |||
| 23 | | Bills | 12/23/2007 | 0-1 | +115 | vs | -135 | L 21-38 | +2.5 | -14.5 (N) | 32 | +27 (O) | 3 | 16 | 244 | 383 | 11.1 | 0.0 | ||
| 24 | | Bills | 12/30/2007 | 0-0-1 | +325 | @ | -400 | L 9-17 | +8 | 0 (P) | 38.5 | -12.5 (U) | 0 | 13 | 271 | 391 | 16.7 | 50.0 | ||
| 25 | | Bills | 9/7/2008 | 1-0 | -130 | vs | +110 | W 34-10 | -1.5 | +22.5 (Y) | 39.5 | +4.5 (O) | 4 | 13 | 338 | 252 | 25.0 | 100.0 | ||
| Average | 0.7 | 2.4 | 18.2 | 313.8 | 339.7 | 36.3 | 0.0 | |||||||||||||
| Total | 42-31-8 | 193 | 1,477 | 25,420 | 27,516 | 36.3 | 44.6 | |||||||||||||
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Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |