| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Buffalo Bills | -111 | @ | -107 | WK 1 | Sun, Sep 13, 2026 | 1:00 PM | -1.5 | 44.5 | |
| 2 | | Buffalo Bills | -157 | vs | +133 | WK 2 | Thu, Sep 17, 2026 | 8:15 PM | -3.0 | 52.5 | |
| 3 | | Buffalo Bills | -170 | vs | +138 | WK 3 | Sun, Sep 27, 2026 | 1:00 PM | -3.0 | 48.5 | |
| 4 | | Buffalo Bills | -181 | vs | +150 | WK 4 | Sun, Oct 4, 2026 | 1:00 PM | -3.0 | 49.5 | |
| 5 | | Buffalo Bills | +160 | @ | -193 | WK 5 | Mon, Oct 12, 2026 | 8:15 PM | +3.0 | 53.5 | |
| 6 | | Buffalo Bills | -156 | vs | +132 | WK 12 | Thu, Nov 26, 2026 | 8:20 PM | -2.5 | 50.5 | |
| 7 | | Buffalo Bills | -127 | @ | +107 | WK 16 | Fri, Dec 25, 2026 | 4:30 PM | -1.5 | 46.5 |
Betting lines shown represent consensus, closing odds.
More NFL News
Mike Macdonald: Titans QB Cam Ward 'in command' during Seahawks-Titans joint practice
Fernando Mendoza has plenty of experience to rely on in Raiders quarterbacks room
Macdonald: Seahawks WR Jake Bobo to get tests for a serious right knee injury
Jacksonville Jaguars prepare for a home season under construction with stadium getting renovated
Tempers are flaring, fists are flying around the NFL during joint practices
Reigning NFL rushing champion James Cook is underpaid but he's focused on helping the Bills win
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |