The Buffalo Bills have a record of 52-45-1 against the spread in the regular season against the AFC at home since 2010.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/12/2010 | 0-1 | +150 | vs | -170 | L 10-15 | +3 | -2 (N) | 39.5 | -14.5 (U) | 1 | 9 | 166 | 296 | 21.4 | 33.3 | ||
| 2 | | Bills | 10/3/2010 | 0-1 | +210 | vs | -250 | L 14-38 | +5.5 | -18.5 (N) | 36.5 | +15.5 (O) | 2 | 12 | 223 | 444 | 0.0 | 100.0 | ||
| 3 | | Bills | 10/10/2010 | 0-1 | -140 | vs | +120 | L 26-36 | -1 | -11 (N) | 41 | +21 (O) | 3 | 17 | 306 | 381 | 27.3 | 0.0 | ||
| 4 | | Bills | 11/28/2010 | 1-0 | +250 | vs | -300 | L 16-19 | +6.5 | +3.5 (Y) | 43.5 | -8.5 (U) | 1 | 19 | 329 | 426 | 30.8 | 100.0 | ||
| 5 | | Bills | 12/12/2010 | 1-0 | -110 | vs | -110 | W 13-6 | -1 | +6 (Y) | 39 | -20 (U) | 1 | 19 | 323 | 187 | 35.7 | 50.0 | ||
| 6 | | Bills | 12/26/2010 | 0-1 | +290 | vs | -350 | L 3-34 | +7 | -24 (N) | 45 | -8 (U) | 0 | 16 | 369 | 348 | 30.0 | 33.3 | ||
| 7 | | Bills | 9/18/2011 | 0-1 | -200 | vs | +175 | W 38-35 | -4 | -1 (N) | 41 | +32 (O) | 5 | 34 | 481 | 454 | 36.4 | 100.0 | ||
| 8 | | Bills | 9/25/2011 | 1-0 | +280 | vs | -340 | W 34-31 | +7 | +10 (Y) | 54 | +11 (O) | 4 | 24 | 448 | 495 | 36.4 | 0.0 | ||
| 9 | | Bills | 11/6/2011 | 0-1 | -135 | vs | +115 | L 11-27 | -2.5 | -18.5 (N) | 45 | -7 (U) | 1 | 14 | 287 | 348 | 27.3 | 33.3 | ||
| 10 | | Bills | 12/4/2011 | 0-1 | -120 | vs | +100 | L 17-23 | -1 | -7 (N) | 42.5 | -2.5 (U) | 2 | 18 | 386 | 317 | 43.8 | 50.0 | ||
| 11 | | Bills | 12/18/2011 | 0-1 | -110 | vs | -110 | L 23-30 | -1 | -8 (N) | 42 | +11 (O) | 3 | 21 | 404 | 448 | 0.0 | 100.0 | ||
| 12 | | Bills | 12/24/2011 | 1-0 | +130 | vs | -150 | W 40-14 | +3 | +29 (Y) | 42.5 | +11.5 (O) | 4 | 14 | 351 | 285 | 16.7 | |||
| 13 | | Bills | 9/16/2012 | 1-0 | -165 | vs | +145 | W 35-17 | -3 | +15 (Y) | 45 | +7 (O) | 5 | 15 | 379 | 422 | 41.7 | |||
| 14 | | Bills | 9/30/2012 | 0-1 | +175 | vs | -210 | L 28-52 | +4 | -20 (N) | 48.5 | +31.5 (O) | 4 | 19 | 438 | 580 | 53.3 | |||
| 15 | | Bills | 10/21/2012 | 0-1 | -215 | vs | +185 | L 34-35 | -4 | -5 (N) | 46.5 | +22.5 (O) | 4 | 22 | 382 | 390 | 58.3 | 0.0 | ||
| 16 | | Bills | 11/15/2012 | 1-0 | -140 | vs | +120 | W 19-14 | -2.5 | +2.5 (Y) | 46 | -13 (U) | 1 | 18 | 281 | 184 | 16.7 | |||
| 17 | | Bills | 12/2/2012 | 1-0 | -265 | vs | +225 | W 34-18 | -6 | +10 (Y) | 41 | +11 (O) | 4 | 20 | 344 | 236 | 41.7 | 0.0 | ||
| 18 | | Bills | 12/30/2012 | 1-0 | -180 | vs | +160 | W 28-9 | -3.5 | +15.5 (Y) | 41 | -4 (U) | 4 | 16 | 334 | 332 | 46.7 | 100.0 | ||
| 19 | | Bills | 9/8/2013 | 1-0 | +400 | vs | -500 | L 21-23 | +10 | +8 (Y) | 50.5 | -6.5 (U) | 3 | 15 | 286 | 431 | 30.8 | |||
| 20 | | Bills | 9/29/2013 | 1-0 | +145 | vs | -165 | W 23-20 | +3 | +6 (Y) | 44.5 | -1.5 (U) | 2 | 19 | 350 | 345 | 27.8 | |||
| 21 | | Bills | 10/13/2013 | 1-0 | +230 | vs | -270 | L 24-27 | +6 | +3 (Y) | 41.5 | +9.5 (O) | 3 | 20 | 322 | 483 | 47.1 | 50.0 | ||
| 22 | | Bills | 11/3/2013 | 0-1 | +195 | vs | -235 | L 13-23 | +4.5 | -5.5 (N) | 40.5 | -4.5 (U) | 1 | 25 | 470 | 210 | 30.8 | 0.0 | ||
| 23 | | Bills | 11/17/2013 | 1-0 | +110 | vs | -130 | W 37-14 | +2 | +25 (Y) | 39 | +12 (O) | 4 | 14 | 313 | 267 | 42.1 | 100.0 | ||
| 24 | | Bills | 12/22/2013 | 1-0 | -120 | vs | +100 | W 19-0 | -1 | +18 (Y) | 42 | -23 (U) | 1 | 18 | 390 | 103 | 36.8 | |||
| 25 | | Bills | 9/14/2014 | 1-0 | -120 | vs | +100 | W 29-10 | -1 | +18 (Y) | 43 | -4 (U) | 2 | 13 | 315 | 290 | 33.3 | |||
| Average | 0.5 | 3.0 | 20.2 | 356.2 | 324.8 | 40.4 | 0.0 | |||||||||||||
| Total | 52-45-1 | 295 | 1,984 | 34,903 | 31,827 | 40.4 | 50.0 | |||||||||||||
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More Bills Stats
Team Leaders 
PASS
1,039
Allen
RUSH
421
Cook
REC
270
Kincaid
Team Rankings
PPG
31.8
2nd
OPP PPG
26.8
25th
RUSH YDS/G
139.0
6th
PASS YDS/G
259.8
10th
Jets
LAR
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Cowboys
Commanders
Packers
Lions
Bears
Panthers
Falcons
Buccaneers
Saints
49ers
Seahawks
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
Colts
Texans
Chargers